Results 81 to 90 of about 5,682,532 (321)

Assessment and Predicting Factors of Repeated Brain Computed Tomography in Traumatic Brain Injury Patients for Risk-Stratified Care Management: A 5-Year Retrospective Study

Neurology Research International, 2016
Background and Objective. To determine the value of repeated brain CT in TBI cases for risk-stratified care management (RSCM) and to identify predicting factors which will change the neurosurgical management after repeated brain CTs. Methods.
Preeda Sumritpradit, Thitipong Setthalikhit, Dr.Sorayouth Chumnanvej   +2 more
semanticscholar   +1 more source

NCCN resource‐stratified and harmonized guidelines: A paradigm for optimizing global cancer care

Cancer, 2020
Clinical practice guidelines in oncology lead to improved outcomes in care. However, the most frequently used guidelines are developed for highly resourced systems.
W. Koh, B. Anderson, R. Carlson
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

The science of clinical practice: disease diagnosis or patient prognosis? Evidence about "what is likely to happen" should shape clinical practice. [PDF]

, 2015
BACKGROUND: Diagnosis is the traditional basis for decision-making in clinical practice. Evidence is often lacking about future benefits and harms of these decisions for patients diagnosed with and without disease.
A Chauffard, A Vickers, AD Hingorani, Adam Timmis, AJ Vickers, Alastair D Hay, C Mar Del, CK Lee, DA Asch, Danielle A Van Der Windt, DE Newby, Douglas G Altman, E Rosenberg Charles, E Stolper, EAM Gale, EW Steyerberg, G-J Dinant, George Peat, H Downing, H Hemingway, Harry Hemingway, HG Welch, HM Krumholz, I Roberts, Ian Roberts, Independent UK Panel on Breast Cancer Screening, J Vestbo, J Wellwood, JC Hill, JG Jarvik, Jonathan J Deeks, Jutel Annemarie Goldstein, Kate M Dunn, L Ferrante di Ruffano, Linda LeResche, M Korff Von, M Roland, Michael Sharpe, Michael Von Korff, O Bruder, P Brown, Pablo Perel, PD White, Peter Croft, PM Bossuyt, R Aronowitz, R Moynihan, R Smith-Bindman, RA Aronowitz, Richard D Riley, Richard J Stevens, RK Simmons, RO Bonow, SJ Lord, SS Watson, Steffen E Petersen, TB Murdoch, WJ Katon   +57 more
core   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Healthcare utilization and adverse outcomes stratified by sex, age and long-term care residency using the Alberta COVID-19 Analytics and Research Database (ACARD): a population-based descriptive study [PDF]

, 2023
Elissa Rennert‐May, Alysha Crocker, Adam G. D’Souza, Zuying Zhang, Derek S. Chew, Reed F. Beall, David Vickers, Jenine Leal   +7 more
openalex   +1 more source

Computer-Based Stratified Primary Care for Musculoskeletal Consultations Compared With Usual Care: Study Protocol for the STarT MSK Cluster Randomized Controlled Trial

JMIR Research Protocols, 2020
Background Musculoskeletal (MSK) pain is a major cause of pain and disability. We previously developed a prognostic tool (Start Back Tool) with demonstrated effectiveness in guiding primary care low back pain management by supporting decision making ...
Jonathan C Hill, S. Garvin, Ying Chen, V. Cooper, S. Wathall, B. Bartlam, B. Saunders, Martyn Lewis, J. Protheroe, A. Chudyk, H. Birkinshaw, K. Dunn, S. Jowett, Raymond Oppong, E. Hay, D. A. van der Windt, C. Mallen, N. Foster   +17 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Effectiveness and Cost-Effectiveness of a Stratified Blended Physiotherapy Intervention Compared With Face-to-Face Physiotherapy in Patients With Nonspecific Low Back Pain: Cluster Randomized Controlled Trial

Journal of Medical Internet Research, 2023
BackgroundNonspecific low back pain (LBP) is a leading contributor to disability worldwide, and its socioeconomic burden is substantial.
Tjarco Koppenaal, Johanna M van Dongen, Corelien JJ Kloek, Remco M Arensman, Cindy Veenhof, Martijn F Pisters, Raymond WJG Ostelo   +6 more
doaj   +1 more source