Results 41 to 50 of about 94,207 (269)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Free convective flow of a stratified fluid through a porous medium bounded by a vertical plane
International Journal of Mathematics and Mathematical Sciences, 1994 Steady two-dimensional free convection flow of a thermally stratified viscous fluid through a highly porous medium bounded by a vertical plane surface of varying temperature, is considered.
H. K. Mondal, T. K. Chaudhury
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Vertical Round Buoyant Jets and Fountains in a Linearly, Density-Stratified Fluid
Fluids, 2020 Turbulent round buoyant jets and fountains issuing vertically into a linearly density-stratified calm ambient have been investigated in a series of laboratory experiments.
Panos N. Papanicolaou +1 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Waves due to initial disturbances at the inertial surface in a stratified fluid of finite depth
International Journal of Mathematics and Mathematical Sciences, 2000 This paper is concerned with a Cauchy-Poisson problem in a weakly stratified ocean of uniform finite depth bounded above by an inertial surface (IS). The inertial surface is composed of a thin but uniform distribution of noninteracting materials.
Prity Ghosh, Uma Basu, B. N. Mandal
doaj +1 more source
Results in Physics, 2016 This communication explores the effects of homogeneous-heterogeneous reactions in thermally stratified mixed convection flow of an Oldroyd-B fluid. Flow situation is addressed when the diffusion coefficients of the reactant and auto catalyst are equal ...
T. Hayat, Zakir Hussain, A. Alsaedi
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source