Results 71 to 80 of about 94,207 (269)

Analysis of nonlinear stratified convective flow of Powell-Eyring fluid: Application of modern diffusion

open access: yesAdvances in Mechanical Engineering, 2020
The stratification phenomena have great importance in fishery management, insufficiency of dissolved oxygen in the lower parts of lakes, rivers and ponds, and phytoplankton populations.
Iffat Jabeen   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Effect of heat source and double stratification on MHD free convection in a micropolar fluid

open access: yesAlexandria Engineering Journal, 2015
An attempt has been made to study a steady planar flow of an electrically conducting incompressible viscous fluid on a vertical plate with variable wall temperature and concentration in a doubly stratified micropolar fluid in the presence of a transverse
S.R. Mishra, P.K. Pattnaik, G.C. Dash
doaj   +1 more source

Richtmyer-Meshkov instabilities in stratified fluids [PDF]

open access: yesPhysical Review A, 1985
We present an analytic theory of Richtmyer-Meshkov instabilities in an arbitrary number N of stratified fluids subjected to a shock. Following our earlier work on Rayleigh-Taylor instabilities, the theory assumes incompressible flow in which a shock is treated an impulsive acceleration, g = ..delta..
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Numerical study of double stratification in Casson fluid flow in the presence of mixed convection and chemical reaction

open access: yesResults in Physics, 2017
In this article, mixed convection MHD Casson fluid flow towards an inclined stretching cylindrical surface in a double stratified medium is considered. The flow field situation is manifested with heat generation/absorption and chemical reaction effects ...
Khalil Ur Rehman   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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