Results 161 to 170 of about 10,169,362 (317)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Mapping forest aboveground carbon stock of combined stratified sampling and RFRK model with mean annual temperature and precipitation. [PDF]
Sci RepPeng M +5 more
europepmc +1 more source
A log rank type test in observational survival studies with stratified sampling. [PDF]
Lifetime Data Anal, 2016 Bai X, Tsiatis AA.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Evidence of Fine-Scale Genetic Structure in Tiger Sharks (<i>Galeocerdo cuvier</i>) Highlights the Importance of Stratified Sampling Regimes. [PDF]
Evol ApplFish JJ +9 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
A new ensemble learning method stratified sampling blending optimizes conventional blending and improves prediction performance. [PDF]
Bioinform AdvMiao N +7 more
europepmc +1 more source
Knowledge, attitudes, and perceptions of autism spectrum disorder in a stratified sampling of preschool teachers in China. [PDF]
BMC Psychiatry, 2016 Liu Y +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source