Results 121 to 130 of about 6,538,520 (302)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Rapid antigen detection of severe acute respiratory syndrome coronavirus-2 in stray cats: A cross-sectional study [PDF]

Veterinary World
Background and Aim: Although reverse zoonotic transmission events from humans to domestic cats have been described, there is currently little evidence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) circulation in stray cats.
Ronaldy Santana Santos, Daniel Antônio Braga Lee, Marina dos Santos Barreto, Eloia Emanuelly Dias Silva, Pamela Chaves de Jesus, Pedro Henrique Macedo Moura, Deise Maria Rego Rodrigues Silva, Jessiane Bispo de Souza, Taynar Lima Bezerra, Patricia Oliveira Meira Santos, Adriana Gibara Guimarães, Lucas Alves da Mota Santana, Carlos Roberto Prudencio, Lysandro Pinto Borges   +13 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Study of Giardia Infection in Cats [PDF]

Iranian Journal of Public Health, 2006
Giardiasis caused by the intestinal flagellate Giardia duodenalis. It is postulated that animals may be a reservoir for human infection and vice versa, thus, giardiasis classified as a zooanthroponotic disease.
M Zarebavani, A Pezeshki, Sh Jamshidi, M Rezaeian   +3 more
doaj   +2 more sources

Population Structure of Bartonella henselae in Algerian Urban Stray Cats

PLoS ONE, 2012
Whole blood samples from 211 stray cats from Algiers, Algeria, were cultured to detect the presence of Bartonella species and to evaluate the genetic diversity of B. henselae strains by multiple locus VNTR analysis (MLVA). Bartonella henselae was the only species isolated from 36 (17%) of 211 cats. B.
Azzag, Naouelle, Haddad, Nadia, Durand, Benoit, Petit, Elisabeth, Ammouche, Ali, Chomel, Bruno, Boulouis, Henri-Jean   +6 more
openaire   +7 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Bacteriology of vaccinated and non-vaccinated eye of cats. [PDF]

, 2010
Thirty cats were divided into two groups: group 1 (owner-kept cats) and group 2 (stray cats). Group 1 consisted of 11 cats in which the vaccination status was up to date whereas group 2 consisted of 19 cats in which the vaccination status was unknown ...
Ismail, Nora, Sabri, Jasni
core  

Urban Cat Management in Australia—Evidence-Based Strategies for Success

Animals
Simple Summary Free-roaming cats in urban areas are a persistent challenge. Traditional management strategies, such as containment laws, impounding, and fines, have proven ineffective, particularly in low-income areas, where most free-roaming cats are ...
Jennifer Cotterell, Jacquie Rand, Rebekah Scotney   +2 more
semanticscholar   +1 more source