Results 61 to 70 of about 3,607,382 (286)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

National Ignition Facility main laser stray light analysis and control [PDF]

, 1998
Stray light analysis has been carried out for the main laser section of the National Ignition Facility main laser section using a comprehensive non-sequential ray trace model supplemented with additional ray trace and diffraction propagation modeling ...
Peterson, G, Miller, J L, Schweyen, J, English, R E   +3 more
core  

Stray-light contamination and spatial deconvolution of slit-spectrograph observations

, 2011
Context. Stray light caused by scattering on optical surfaces and in the Earth’s atmosphere degrades the spatial resolution of observations.
C. Beck, D. Fabbian, R. Rezaei
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Stray Light–Induced Multifocal Electroretinograms

Investigative Opthalmology & Visual Science, 2003
To evaluate the characteristics of stray light-induced response in multifocal ERG (mfERG) elicited by the stimulus falling on the disc.A patient with an enlarged optic disc (4 x 4 disc diameters of disc of normal fellow eye) and four normal volunteers served as subjects. The mfERGs elicited by different stimulus intensities (0.67-4.67 cd-sec/m(2)) were
Yoshiaki, Shimada, Masayuki, Horiguchi
openaire   +2 more sources

Stray Light Measurement for Point Source Transmittance of Space Optical Systems

, 2016
The increased sensitivity of space-based sensors has imposed greater stray light performance goals on telescope design. To meet the demand, a stray light test station for measuring point source transmission (PST) has been built with a lower threshold ...
Xu, Liang, Chen, Qinfang, Ma, Zhen, Li, Xinyao, Chen, QF (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, Xian 710119, Peoples R China., Pang, Zhihai, Li, Zhaohui   +6 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Impact of mirror local defects on system scattering in telescopes

Results in Physics
To calculate the scattering impact of scratches on space-based telescope systems accurately, this study proposes fitting scratch scattering using an anisotropic scattering model based on actual test results.
Zhongkai Liu, Jincheng Wang, Rongkuan Leng, Xiaokun Wang, Min Zhang, Jing Wang, Mengxue Cai, Wenhan Li, Bin Liu, Lingzhong Li, Qiang Cheng, Longxiang Li, Xiao Luo, Xuejun Zhang   +13 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source