Results 31 to 40 of about 460,908 (314)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Learning Deep Belief Networks from Non-Stationary Streams [PDF]

open access: yes, 2012
18.10.13 KB. Ok to add author version to spiral from LNCS; embargo period expired. SpringerDeep learning has proven to be beneficial for complex tasks such as classifying images. However, this approach has been mostly applied to static datasets.
Pouzols, Federico Montesino   +11 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

مصر بين الحركة الوطنية والاستراتيجية البريطانية ١٨٧١-١٨٨٢: دراسة تحليلية [PDF]

open access: yesMağallaẗ Kulliyyaẗ Al-Adāb Bi-Qinā
تعالج هذه الدراسة موضوع تبلور الفكر الوطنى النهضوى فى مصر بقدوم المفكر الإصلاحي "جمال الدين الأفغاني" إليها في مارس من العام ١٨٧١م من الأستانة (استانبول حاليا) عاصمة الدولة العثمانية والذى رحب به "الخديوى إسماعيل" حاكم مصر والسودان آنذاك لرغبته في ...
رقية عبدالكريم فرج الله على
doaj   +1 more source

Quantifying the Spatial Variability of Annual and Seasonal Changes in Riverscape Vegetation Using Drone Laser Scanning

open access: yesDrones, 2021
Riverscapes are complex ecosystems consisting of dynamic processes influenced by spatially heterogeneous physical features. A critical component of riverscapes is vegetation in the stream channel and floodplain, which influences flooding and provides ...
Jonathan P. Resop   +2 more
doaj   +1 more source

On Streams of Events and Mixtures of Streams

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1966
Summary Distribution functions for streams of events (and, in particular, for the length of the interval “between successive events”) are defined within the framework of the theory of Khintchine (1955). Relationships such as that between the distributions for the length of an “arbitrary interval” between successive events, the ...
openaire   +2 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

On the impossibility of representing infinite utility streams [PDF]

open access: yes, 2007
We show that, independently of the topology chosen on the set of all infinity utility streams, there is no Social Welfare Function preserving the von Weizsäcker’s overtaking criterion.
Núñez Sanz, Carmelo   +5 more
core   +1 more source

Freshwater Fishes of the State of Rio de Janeiro, Southeastern Brazil: Biogeographic and Diversity Patterns in a Historically Well-Sampled Territory

open access: yesEcologies
The fish fauna of Rio de Janeiro has been extensively studied, resulting in a comprehensive database of species collected over more than three centuries.
Luisa M. Sarmento-Soares   +2 more
doaj   +1 more source

Macroalgas de riachos da Serra da Prata, leste do Estado do Paraná, Sul do Brasil Stream macroalgae from Serra da Prata, eastern Paraná State, Southern Brazil

open access: yesActa Botânica Brasílica, 2008
Estudos florísticos das comunidades de macroalgas lóticas no Brasil são quase que exclusivamente baseadas em material do Estado de São Paulo. Informações sobre macroalgas de riachos são escassos no Estado do Paraná.
Cleto Kaveski Peres   +2 more
doaj   +1 more source

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