Results 41 to 50 of about 797,588 (268)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Feasibility Study of Magnesium Slag, Fly Ash, and Metakaolin to Replace Part of Cement as Cementitious Materials

Buildings
To achieve the efficient utilization of magnesium slag, this study investigates the use of magnesium slag, fly ash, and metakaolin as partial substitutes for cement in cementitious materials.
Fulu Wei, Hairong Xiao, Jia Zhang, Zhenqing He, Xuanhao Cao, Bowen Guan   +5 more
doaj   +1 more source

Machine Learning-Based Empirical Formulations for Strength Properties of Steel Fiber Reinforced Concrete [PDF]

Journal of Rehabilitation in Civil Engineering
The accurate approximation is a benefit of the modern machine learning technique, which also disappeared the problems of traditional empirical methods, such as human and technical errors plus environmental pollution.
Mohammad Hossein Taghavi Parsa, Mohammad Reza Adlparvar, Morteza Esmaeili   +2 more
doaj   +1 more source

Effect of Storage Temperature on Selected Strength Parameters of Dual-Cured Composite Cements

Journal of Functional Biomaterials, 2023
Direct restorations are currently the most popular restorations used in dental prosthodontics. Due to the increased requirements for materials used in the fabrication of fixed restorations, there is a need for evaluation of strength parameters of these ...
Joanna Giełzak, Agata Szczesio-Wlodarczyk, Kinga Bociong   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A SELECTION OF THE PARAMETERS OF THE ENERGY POTENTIAL OF THE IMPACT EXECUTIVE BODIES AND THE PREDICTION OF THEIR RESOURCE (in Russian) [PDF]

Management Systems in Production Engineering, 2013
The article describes received by the author multifactorial models of fracture of materials according to the technological scheme typical for building and road machines.
Victor NORDIN
doaj  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Strength properties of aluminum alloys in 115 MPa hydrogen gas

Nihon Kikai Gakkai ronbunshu, 2018
Four types of strength tests, slow strain rate tensile (SSRT), fatigue life, fatigue crack growth (FCG) and fracture toughness tests, were performed on six types of aluminum alloys, 5083-O, 6061-T6, 6066-T6, 7N01-T5, 7N01-T6 and 7075-T6, in air and 115 ...
Saburo MATSUOKA, Takashi IIJIMA, Satoko YOSHIDA, Hisao MATSUNAGA, Junichiro YAMABE   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source