Results 41 to 50 of about 3,138,437 (306)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Effects of load types and critical molar ratios on strength properties and geopolymerization mechanism

Reviews on Advanced Materials Science, 2021
In this study, the effect of SiO2/Al2O3 (S/A), Na2O/Al2O3 (N/A) and H2O/Na2O (H/N) molar ratios on bending and compressive strength of geopolymer were investigated. The geopolymerization mechanism was also analyzed from microstructure difference by FTIR.
Meng Tao, Ahmed Sara, Dai Dawang, Yu Yue
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The use of different forms of hydroxyapatite to create a bioactive coating on a porous titanium-base [PDF]

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2018
The article discusses methods of creating a bioactive composite on a porous titanium base. The possibility of formation of coatings based on colloidal hydroxyapatite and an aqueous suspension of powder hydroxyapatite in various ways has been studied. The
E.A. Bogdanova, V.M. Skachkov, A.G. Shirokova, N.A. Sabirzyanov   +3 more
doaj   +1 more source

Functional properties of acid‐thinned potato starch: impact of modification, molecular starch characteristics, and solution preparation [PDF]

, 2019
A matrix of 27 acid‐thinned (AT) potato starch (PS) samples is prepared in a laboratory scale in slurry by gradation of the process parameters temperature (30, 40, and 50 °C), acid concentration (0.3, 0.6, and 0.9 m HCl) and time (4, 10, and 20 h), and ...
Flöter, Eckhard, Ulbrich, Marco
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Lignosulfonate as a Strength Additive for Non-Wood Paperboard [PDF]

, 2000
Recycle mills that use old corrugated cardboard (OCC) in their furnish experience difficulties in maintaining the quality of the paperboard produced. Recycle mills using the OCC collect their OCC from many parts of the world.
Martin, Francisco L.
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Mechanical Properties of Frozen Glacial Tills due to Short Periods of Thawing

Frontiers in Earth Science, 2021
Due to the warming climate, glacier retreat has left massive glacial tills in steep gullies; ice in the soil is prone to change phase resulting in the decrease of the ice strength and bonding of soil particles; collapse of thawing tills can lead to ...
Yanju Fu, Yanju Fu, Yao Jiang, Yao Jiang, Yao Jiang, Jiao Wang, Jiao Wang, Ziming Liu, Ziming Liu, Xingsheng Lu, Xingsheng Lu   +10 more
doaj   +1 more source