Results 51 to 60 of about 559,013 (263)
A Strengthening of Brooks' Theorem
Journal of Combinatorial Theory, Series B, 1999 This paper mainly proves the conjecture due to \textit{A. Beutelspacher} and \textit{P.-R. Hering} [Ars Comb. 18, 201-216 (1984; Zbl 0554.05025)]. More precisely, the author proves that for sufficiently large \(\Delta\), any graph with maximum degree at most \(\Delta\) and no cliques of size \(\Delta\) has a \(\Delta-1\) colouring.
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Journal of Natural FibersModern research is focused on the discovery of new compounds that meet the requirements of modern construction. An example of low energy consumption is that buildings consume between 20% and 40% of energy.
Abdelkader Fidjah +7 more
doaj +1 more source
Strengthening the remaining synapses [PDF]
Science, 2017 Neuroscience Working memory depends in part on the proper activation of neural circuits in a brain area called the dorsolateral prefrontal cortex (DLPFC). In primates, DLPFC performance during working memory tasks improves through adolescence. Synaptic pruning eliminates unwanted or imprecise connections and strengthens the remaining connections. Chung
openaire +2 more sources
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Serie Científica de la Universidad de las Ciencias Informáticas, 2021 Las políticas de seguridad de la información basadas en la norma ISO 27002 para el departamento de sistemas informáticos de la Universidad Estatal de South Manabí tienen como objetivo asegurar la fidelidad de la información institucional que salvaguarda
Cristhian José Álava Mero +2 more
doaj +4 more sources
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source