Results 101 to 110 of about 5,576,996 (326)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Development of Strategy: Scanning and Forecasting of External and Internal Environments

open access: yesУправленческое консультирование, 2018
Scanning and Forecasting the Dynamics of External and Internal Environments, Opportunities, Threats, Strengths, and Weaknesses.
Vladimir Lvovich Kvint
doaj  

Complete characterization of sink-strengths for 1D to 3D mobilities of defect clusters.II. Bridging between limiting cases with effective sink-strengths calculations

open access: yes, 2020
In a companion paper, we proposed new analytical expressions of cluster sink-strengths (CSS) indispensable to any complete parameterization of rate equations cluster dynamics accounting for reaction between defect clusters populations having a 1D ...
Adjanor, Gilles
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Systematics of Gamow-Teller strengths in mid-fp-shell nuclei

open access: yes, 1994
We show that the presently available data on the Gamow-Teller (GT) strength in mid-fp-shell nuclei are proportional to the product of the numbers of valence protons and neutron holes in the full fp-shell. This observation leads to important insights into
Alford   +12 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Vimla Nadkarni: Compassionate and Assertive Doyen of Social Work

open access: yesSpace and Culture, India, 2021
Venkat Rao Pulla
doaj   +1 more source

Home - About - Disclaimer - Privacy