Results 111 to 120 of about 5,576,996 (326)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Strengths of sulfur-basalt concretes [PDF]
Sulfur used in bonding high strength basalt aggregates to form sulfur-basalt ...
Bates, R. C., Crow, L. J.
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Financial area characterisation in the industrial sector of the Boyacá department
Inquietud Empresarial, 2015 This article seeks to make an analysis of the financial management of companies in the industrial sector of Boyacá. By conducting surveys to a random sample of employers, which threw the results in terms of the variables accounting, budgeting, tax, costs,
Jorge Enrique Romero Muñoz +1 more
doaj
Report on the Survey of Role-Based Access Control (RBAC) in Practice [PDF]
, 2012 From literature study, we collected: (a) a set of core features of the RBAC model, according to the ANSI/INCITS 359:2004 RBAC standard, (b) implicit assumptions, (c) a set of strengths, and (d) a set of phenomena which may limit these strengths in ...
Condori-Fernándezand, Nelly +2 more
core +1 more source
, 2015 The $^{22}$Ne(p,$\gamma$)$^{23}$Na reaction is included in the neon-sodium cycle of hydrogen burning. A number of narrow resonances in the Gamow window dominates the thermonuclear reaction rate. Several resonance strengths are only poorly known.
Akhmadaliev, Shavkat +13 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source