Results 131 to 140 of about 5,576,996 (326)

The Strengths and Difficulties Questionnaire: a research note.

Journal of Child Psychology and Psychiatry and Allied Disciplines, 1997
R. Goodman
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

The Clinical Frailty Scale is a valid and independent predictor of one-year survival in patients sustaining a hip fracture: scottish Hip Fracture Audit data from 8,092 patients

Bone & Joint Open
Aims: Hip fracture patients have a significant mortality risk. Risk stratification tools are important in guiding management and family discussions.
Matthew J. Kennedy, Rose S. Penfold, Lorraine Donaldson, Andrew J. Hall, Martin J. Davison, Alasdair M. J. MacLullich, Phil Walmsley, Nick D. Clement, Jon V. Clarke   +8 more
doaj   +1 more source

Feasibility of Kevlar 49/PMR-15 Polyimide for High Temperature Applications [PDF]

Kevlar 49 aramid organic fiber reinforced PMR-15 polyimide laminates were characterized to determine the applicability of the material to high temperature aerospace structures.
Hanson, M. P.
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Scrutinizing the Perspective of Family Physician Teams After the first Decade of Implementation of Urban Family Physician Program: A Thematic Qualitative Study from Iran

International Journal of Preventive Medicine
Background: Urban Family Physician Program (UFPP) passed the first ten years of its age in Iran. In this study, we aimed to determine the strengths and challenges of this program from the viewpoints of family physician (FP) teams to address comprehensive
Behnam Honarvar, Kamran Bagheri Lankarani, Hassan Joulaei, Saeed Shahabi, Milad Ahmadi Marzaleh, Yasamin Kaheni, Niloofar Rambod Rad, Zahra Zarei Jeliani, Fatemeh Shaygani, Majid Najafi Kalyani, Maedeh Hajiaghaei, Fatemeh Zarei Jeliani   +11 more
doaj   +1 more source