Results 31 to 40 of about 808,099 (278)

Brazilian nursing journals: strengths, weaknesses and challenges

Revista Brasileira de Enfermagem
Objective: To evaluate, qualitatively, the Brazilian nursing journals and identify their strengths and weaknesses when compared to international journals in the area. Methods: A historic approach regarding the period from 2012 to 2016.
Magdalena Jose Avena, Dulce Aparecida Barbosa   +1 more
doaj   +1 more source

Machine Learning in Chemical Engineering: Strengths, Weaknesses, Opportunities, and Threats

Engineering, 2021
Chemical engineers rely on models for design, research, and daily decision-making, often with potentially large financial and safety implications. Previous efforts a few decades ago to combine artificial intelligence and chemical engineering for modeling
Maarten R. Dobbelaere, Pieter P. Plehiers, Ruben Van de Vijver, Christian V. Stevens, Kevin M. Van Geem   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Rates and Rocks: Strengths and Weaknesses of Molecular Dating Methods

Frontiers in Genetics, 2020
I present here an in-depth, although non-exhaustive, review of two topics in molecular dating. Clock models, which describe the evolution of the rate of evolution, are considered first.
Stéphane Guindon
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Methods for comparing scanpaths and saliency maps: strengths and weaknesses [PDF]

, 2012
International audienceIn this article, we are interested in the computational modeling of visual attention. We report methods commonly used to assess the performance of these kinds of models.
Baccino, Thierry, Le Meur, Olivier
core   +4 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

BOOK REVIEW OF DEAD POETS SOCIETY WRITTEN BY N.H. KLEINBAUM [PDF]

, 2015
This review analyzes the strengths and weaknesses of N.H. Kleinbaum's Dead Poets Society. Dead Poets Society is a novel that tells a story about a journey of an English literature teacher who provides non-conventional teaching methods in literature. This
Ariyani, Linda Dwi
core   +1 more source