Results 51 to 60 of about 808,099 (278)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Reference Intervals: Strengths, Weaknesses, and Challenges [PDF]

Clinical Chemistry, 2016
A reference interval (RI)10 is a standard component of reporting a laboratory result and is important to transform a numerical value into clinically meaningful information. An RI is intended to inform the clinical care provider that laboratory values within the interval indicate a nondiseased condition.
Miller, W Greg, Horowitz, Gary L, Ceriotti, Ferruccio, Fleming, James K, Greenberg, Neil, Katayev, Alexander, Jones, Graham R D, Rosner, William, Young, Ian S   +8 more
openaire   +3 more sources

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Elaborating on the strengths and weaknesses of the evaluation status and quality assurance of e-learning in universities of medical sciences [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2021
Introduction: Identifying the strengths and weaknesses of evaluation and quality assurance of an e-learning system can help design the systematic structure of the evaluation process in the higher education to elevate the quality of education.
Kaveh Eslami, Hatam Boostani, Mansour Zahiri, Simin Jahani, Behzad Fouladi Dehaghi, Arash Salahshori, Reza Arjmand, Akbar Babaei Heydarabadi   +7 more
doaj  

Glioblastoma preclinical models: Strengths and weaknesses

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Glioblastoma multiforme is a highly malignant brain tumor with significant intra- and intertumoral heterogeneity known for its aggressive nature and poor prognosis. The complex signaling cascade that regulates this heterogeneity makes targeted drug therapy ineffective.
Pasupuleti, Vasavi, Vora, Lalitkumar, Prasad, Renuka, Nandakumar, D.N., Khatri, Dharmendra Kumar   +4 more
openaire   +4 more sources

Ensemble decision systems for general video game playing [PDF]

, 2019
Ensemble Decision Systems offer a unique form of decision making that allows a collection of algorithms to reason together about a problem. Each individual algorithm has its own inherent strengths and weaknesses, and often it is difficult to overcome the
Anderson, Damien, Guerrero-Romero, Cristina, Levine, John, Perez-Liebana, Diego, Rodgers, Philip   +4 more
core   +3 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Universalism and Utilitarianism: An Evaluation of Two Popular Moral Theories in Business Decision Making [PDF]

, 2015
Moral theories remain a topic of interest, not just to moral philosophers, but increasingly in business circles as well, thanks to a tainted reputation that urges more awareness in this regard.
Marques, Joan
core   +2 more sources

Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects [PDF]

, 2009
Staphylococcus aureus in the nose is a risk factor for endogenous staphylococcal infection. UK guidelines recommend the use of mupirocin for nasal decolonization in certain groups of patients colonized with methicillin-resistant S.
Bax, R, Coates, A, Coates, T
core   +2 more sources