Results 251 to 260 of about 439,224 (315)

A dendrimer enhanced CRISPR/Cas12a performance for the evaluation of acidogenic capacity in cariogenic bacteria

open access: yesInterdisciplinary Medicine, EarlyView.
A CRISPR/Cas12a‐powered dendritic DNA nanostructure is assembled to create confined enzymatic microdomains, enabling ultrasensitive detection. Integrated into a paper‐based origami biosensor, it allows equipment‐free on‐site quantification of acidogenic pathogens for the early diagnosis of dental caries.
Yuan Zhang   +4 more
wiley   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

open access: yesInterdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li   +24 more
wiley   +1 more source

High-resolution metagenomic characterization of gut microbiota composition and functional pathways in irritable bowel syndrome. [PDF]

open access: yesSci Rep
Ranasinghe PD   +7 more
europepmc   +1 more source

Early-life carriage and antibiotic resistance of <i>Streptococcus pneumoniae</i> in infants from Sierra Leone. [PDF]

open access: yesFront Microbiol
Chen H   +13 more
europepmc   +1 more source

Comparative analysis of the sputum microbiota in different COPD clinical states. [PDF]

open access: yesSci Rep
Galal L   +4 more
europepmc   +1 more source

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