Results 311 to 320 of about 773,029 (383)

Activity‐Enhancing Mutations in an LmrR‐Based Artificial Metalloenzyme Destabilize the Protein Scaffold and Alter its Conformational Plasticity

open access: yesChemBioChem, EarlyView.
The protein LmrR is a versatile scaffold to design artificial metalloenzymes. Here, we show that the M8D/A92E (DE) mutations that result in a much more efficient catalyst, destabilize the protein dimerization interface and alter the conformation landscape when binding metal cofactor and substrates are shown.
Adil A. Safeer   +5 more
wiley   +1 more source

Ecologic and Economic Evaluation of Combined Methanol Synthesis from CO2 and Biotechnological Upgrading to Value Products. Part 1: Environmental Impact

open access: yesChemie Ingenieur Technik, EarlyView.
The combination of methanol synthesis and biotechnological upgrading to value‐added products still faces some challenges in order to achieve a positive environmental impact and thus the goal of synergetic development of biotechnological and chemical processes.
Mehran Taherkhani   +3 more
wiley   +1 more source

Impact of Chemotherapy Alone and in Combination with Immunotherapy on Oral Microbiota in Cancer Patients-A Pilot Study. [PDF]

open access: yesMicroorganisms
Padure A   +6 more
europepmc   +1 more source

The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts

open access: yesCytoskeleton, EarlyView.
ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena   +4 more
wiley   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

open access: yesCytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius   +6 more
wiley   +1 more source

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