Results 61 to 70 of about 304,728 (296)

The role of the Streptococcus pneumoniae capsule in interactions with complement and phagocytes [PDF]

, 2010
The Streptococcus pneumoniae capsule is an essential virulence factor and it is ideally situated to modulate interactions between the bacteria and host immune cells.
Hyams, C.J.
core  

Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection [PDF]

, 2013
Streptococcus pneumoniae of serotype 3 possess a mucoid capsule and cause disease associated with high mortality rates relative to other pneumococci. Phylogenetic analysis of a complete reference genome and 81 draft sequences from clonal complex 180, the
Mitchell, Tim J, Mitchell, T.J., Hinds, Jason, Susannah J Salter, Janina Dordel (250569), Jason Hinds (41307), Gould, Katherine A, Janina Dordel, Mitchell, AM, Inverarity, D., Birgitta Henriques-Normark (336864), Fookes, Maria C., Julian Parkhill (30393), Harris, Simon R, Fookes, MC, Maria C. Fookes (261889), Salter, SJ, Normark, S., Sarah Browall (469315), Dordel, Janina, Hinds, J, Jason Hinds, Nicholas J Croucher, Zemlickova, Helena, Salter, Susannah J, Barquist, L, Mitchell, Tim J., Inverarity, Donald, Barquist, L., Mitchell, TJ, Staffan Normark, Stephen D Bentley, Katherine A. Gould (469313), Birgitta Henriques-Normark, Andrea M. Mitchell (150475), Gould, KA, Zemlickova, H, Harris, S.R., Susannah J. Salter (466583), Helena Zemlickova (5494223), Julian Parkhill, Maria C Fookes, Fookes, Maria C, Barquist, Lars, Donald Inverarity (469314), Parkhill, Julian, Croucher, NJ, Simon R Harris, Feltwell, Theresa, Croucher, N.J., Simon R. Harris (124597), Henriques-Normark, Birgitta, Gould, Katherine A., Croucher, Nicholas J, Parkhill, J, Harris, Simon R., Theresa Feltwell, Bentley, Stephen D, Lars Barquist (158426), Bentley, Stephen D., Tim J. Mitchell (179143), Gould, K.A., Henriques-Normark, B., Henriques-Normark, B, Feltwell, T, Harris, SR, Theresa Feltwell (66997), Salter, Susannah J., Sarah Browall, Zemlickova, H., Normark, Staffan, Inverarity, D, Bentley, S.D., Hinds, J., Katherine A Gould, Mitchell, Andrea M; id_orcid, Lars Barquist, Mitchell, Andrea M., Bentley, SD, Browall, S, Stephen D. Bentley (137281), Parkhill, J., Donald Inverarity, Staffan Normark (33838), Feltwell, T., Fookes, M.C., Dordel, J., Tim J Mitchell, Mitchell, A.M., Nicholas J. Croucher (158423), Andrea M Mitchell, Browall, S., Dordel, J, Salter, S.J., Browall, Sarah, Normark, S, Helena Zemlickova   +96 more
core   +2 more sources

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Rational Antibacterial Therapy of Respiratory Diseases in children

Zdorovʹe Rebenka, 2013
This article presents the results of bacteriological monitoring of 563 children from Zaporizhzhya and Zaporizhzhya region suffering from acute respiratory infections (ARI). 15.3 % cases ARI was caused by Streptococcus pneumoniae pathogen. The analysis of
G.A. Lezhenko, O.Ye. Pashkova, L.I. Pantyushenko   +2 more
doaj   +1 more source

Risk factors of mortality for children with Streptococcus pneumoniae meningitis

Zhongguo linchuang yanjiu, 2023
Objective To explore the risk factors of mortality for children with Streptococcus pneumococcal meningitis. Methods A retrospective analysis was conducted on the clinical data of 41 hospitalized children diagnosed as Streptococcus pneumoniae menigitis ...
CAI Sha, ZHU Chun-hui, DAI Shu-ming, GAO Mei-ling, HU Yun
doaj   +1 more source

Purification of Disassembled Capsid Protein by Hydroxyapatite Chromatography Enhances Virus‐Like Particle Recovery

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Virus‐like particles (VLPs) are a promising modality with extensive applications in prophylactic and therapeutic vaccine design. Human Papillomavirus (HPV) vaccines are one such example where VLP vaccine applications have led to the successful reduction in HPV‐associated diseases, such as cervical cancer.
Nicholas Samuelson, Nathaniel Parker, Shiyi Wang, Sara Daley, Aaron Cote, Michael A. Winters   +5 more
wiley   +1 more source

RESISTANCE EMERGENCE OF DOXYCYCLINE AGAINST STAPHYLOCOCCUS AUREUS AND STREPTOCOCCUS PNEUONIAE

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine the in vitro sensitivity pattern of doxycycline against the common pathogens namely Staphylococcus aureus and Streptococcus pneumoniae. Study Design: Cross-sectional study.
Rabia Bushra, Mehwish Rizvi, Yousra Shafiq, Maqsood Khan, Farya Zafar, Huma Ali   +5 more
doaj   +2 more sources

Predicting β-lactam susceptibility from the genome of Streptococcus pneumoniae and other mitis group streptococci

Frontiers in Microbiology, 2023
IntroductionFor Streptococcus pneumoniae, β-lactam susceptibility can be predicted from the amino acid sequence of the penicillin-binding proteins PBP1a, PBP2b, and PBP2x.
Helle Brander Eriksen, Kurt Fuursted, Anders Jensen, Christian Salgård Jensen, Xiaohui Nielsen, Xiaohui Nielsen, Jens Jørgen Christensen, Jens Jørgen Christensen, Patricia Shewmaker, Ana Rita Rebelo, Frank Møller Aarestrup, Kristian Schønning, Hans-Christian Slotved, the One Day in Denmark (ODiD) Consortium   +13 more
doaj   +1 more source

Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine [PDF]

, 2013
Streptococcus pneumoniae causes invasive infections, primarily at the extremes of life. A seven-valent conjugate vaccine (PCV7) is used to protect against invasive pneumococcal disease in children.
Nicholas J Loman, Jacqueline Chan, Tocheva Anna S., O’Connor Leigh, Pallen, Mark J., Constantinidou C., Loman, Nicholas J., Pallen M.J., Faust, Saul N, Faust, Saul N., Loman, Nicholas, Clarke S.C., Tocheva A.S., Constantinidou Chrystala, Mark J Pallen, Loman, Nicholas J, Chan, Jacqueline, Constantinidou, Chrystala, Stuart C Clarke, Pallen, Mark J, Gladstone R.A., O'Connor, Leigh, Chrystala Constantinidou, Clarke, Stuart C, Tocheva, Anna S., Faust, S.N., Clarke, S.C., Johanna M C Jefferies, Loman Nicholas J., Faust Saul N., Clarke Stuart C., Gladstone, Rebecca A., Chan J., O’Connor, Leigh, Leigh O'Connor, Anna S Tocheva, Clarke, Stuart C., Pallen, Mark, Tocheva, Anna S, Jefferies J.M.C., Jefferies, Johanna M C, Loman N.J., Chan Jacqueline, Jefferies, Johanna M.C., Gladstone, Rebecca, Saul N Faust, Jefferies Johanna M. C., Jefferies, Johanna M. C., Faust S.N., Pallen Mark J., Gladstone, Rebecca A, Rebecca A Gladstone, O'Connor L., Gladstone Rebecca A.   +53 more
core   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source