Results 61 to 70 of about 289,534 (299)

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

The role of the Streptococcus pneumoniae capsule in interactions with complement and phagocytes [PDF]

, 2010
The Streptococcus pneumoniae capsule is an essential virulence factor and it is ideally situated to modulate interactions between the bacteria and host immune cells.
Hyams, C.J.
core  

Serotypes and antimicrobial resistance of meningeal isolates of Streptococcus pneumonia. Cuba, 2007-2012

VacciMonitor, 2014
An observational study was conducted to know the serotypes and antimicrobial susceptibility of isolates of Streptococcus pneumoniae responsible for meningitis in Cuba, where there is no vaccine yet to prevent invasive pneumococcal disease.
Gilda Toraño-Peraza, Lisania Pías-Solis, Miriam Abreu-Capote, Misladys Rodríguez-Ortega, Félix Dickinson- Meneses, Marlen Varcárcel-Sánchez   +5 more
doaj  

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Rational Antibacterial Therapy of Respiratory Diseases in children

Zdorovʹe Rebenka, 2013
This article presents the results of bacteriological monitoring of 563 children from Zaporizhzhya and Zaporizhzhya region suffering from acute respiratory infections (ARI). 15.3 % cases ARI was caused by Streptococcus pneumoniae pathogen. The analysis of
G.A. Lezhenko, O.Ye. Pashkova, L.I. Pantyushenko   +2 more
doaj   +1 more source

Risk factors of mortality for children with Streptococcus pneumoniae meningitis

Zhongguo linchuang yanjiu, 2023
Objective To explore the risk factors of mortality for children with Streptococcus pneumococcal meningitis. Methods A retrospective analysis was conducted on the clinical data of 41 hospitalized children diagnosed as Streptococcus pneumoniae menigitis ...
CAI Sha, ZHU Chun-hui, DAI Shu-ming, GAO Mei-ling, HU Yun
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative Stress [PDF]

, 2012
Streptococcus pneumoniae is a Gram-positive bacterium which is a member of the normal human nasopharyngeal flora but can also cause serious disease such as pneumonia, bacteremia, and meningitis. Throughout its life cycle, S.
Cecilia A. Hinojosa, Jong, Anne de,, de Jong, Anne; id_orcid, Jetta J. E. Bijlsma, Anne de Jong, Kuipers, Oscar P.; id_orcid, Kuipers, Oscar P., Oscar P. Kuipers, de Jong, Anne, Orihuela, Carlos J.,, Farshchi Andisi, Vahid,, Bijlsma, Jetta J.E.,, Hinojosa, Cecilia A.,, Vahid Farshchi Andisi, Kuipers, Oscar P.,, Carlos J. Orihuela, Farshchi Andisi, Vahid, Bijlsma, Jetta J. E., Hinojosa, Cecilia A., Orihuela, Carlos J.   +19 more
core   +1 more source

RESISTANCE EMERGENCE OF DOXYCYCLINE AGAINST STAPHYLOCOCCUS AUREUS AND STREPTOCOCCUS PNEUONIAE

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine the in vitro sensitivity pattern of doxycycline against the common pathogens namely Staphylococcus aureus and Streptococcus pneumoniae. Study Design: Cross-sectional study.
Rabia Bushra, Mehwish Rizvi, Yousra Shafiq, Maqsood Khan, Farya Zafar, Huma Ali   +5 more
doaj   +2 more sources

Predicting β-lactam susceptibility from the genome of Streptococcus pneumoniae and other mitis group streptococci

Frontiers in Microbiology, 2023
IntroductionFor Streptococcus pneumoniae, β-lactam susceptibility can be predicted from the amino acid sequence of the penicillin-binding proteins PBP1a, PBP2b, and PBP2x.
Helle Brander Eriksen, Kurt Fuursted, Anders Jensen, Christian Salgård Jensen, Xiaohui Nielsen, Xiaohui Nielsen, Jens Jørgen Christensen, Jens Jørgen Christensen, Patricia Shewmaker, Ana Rita Rebelo, Frank Møller Aarestrup, Kristian Schønning, Hans-Christian Slotved, the One Day in Denmark (ODiD) Consortium   +13 more
doaj   +1 more source