Results 51 to 60 of about 6,221,933 (283)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Long-term Benefits of Risk Factor Reduction in Takotsubo Cardiomyopathy.—A Comment on Khalighi et al. Entitled “Takotsubo Cardiomyopathy: A Long Term Follow-up Shows Benefit with Risk Factor Reduction”, J. Cardiovasc. Dev. Dis., 2015, 2, 273–281.

Journal of Cardiovascular Development and Disease, 2016
Takotsubo cardiomyopathy (TC) or stress-induced cardiomyopathy is also popularly referred to as “broken heart syndrome” or “apical ballooning syndrome”. [...]
Shiva P. Ponamgi, Abhishek Deshmukh
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Takotsubo Syndrome: The Secret Crosstalk between Heart and Brain

Reviews in Cardiovascular Medicine, 2023
An acute, transient episode of left ventricular dysfunction characterizes Takotsubo syndrome. It represents about 2% of all cases of acute coronary syndrome (ACS), and occurs predominantly in postmenopausal women, generally following a significant ...
Sofia Schino, Andrea Bezzeccheri, Alessandro Russo, Michela Bonanni, Joseph Cosma, Giuseppe Sangiorgi, Gaetano Chiricolo, Eugenio Martuscelli, Francesco Santoro, Enrica Giuliana Mariano   +9 more
doaj   +1 more source

Stress-induced cardiomyopathy [PDF]

, 2015
A woman in her early 70s presented with chest pain, dyspnoea and diaphoresis 30 min after her husband expired in our hospital. Cardiac markers were elevated and there were acute changes in ECG suggestive for acute coronary syndrome. Echocardiogram showed
Shah, A. B., Levitt, H. L., Coplan, N. B., Lisung, F. G.   +3 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression

Frontiers in Cell and Developmental Biology, 2020
Jumonji domain-containing 3 (JMJD3) protein, a histone demethylase protein, specifically catalyzes the demethylation of H3K27 (H3K27me3) and regulates gene expression.
Panxia Wang, Rui Lan, Zhen Guo, Sidong Cai, Junjian Wang, Quan Wang, Zeyu Li, Zhenzhen Li, Qianqian Wang, Jingyan Li, Zhongkai Wu, Jing Lu, Jing Lu, Jing Lu, Peiqing Liu, Peiqing Liu, Peiqing Liu   +16 more
doaj   +1 more source

Stress-Induced Cardiomyopathy [PDF]

, 2022
Stress-induced cardiomyopathy is a relatively uncommon syndrome with difficult definition. Cases with transient and reversible left ventricular dysfunction, precipitated by emotional stress and without coronary artery disease, are called takotsubo ...
Dallasta, Gonzalo, Avegliano, Gustavo, Ronderos, Ricardo E.   +2 more
core  

Data_Sheet_1_Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling.docx

, 2021
The increasing incidence of stress-induced cardiomyopathy is due to the complexities of our modern-day lives, which constantly elicit stress responses.
Hong Sun (132232), Kexue Li (798708), Joseph Adu-Amankwaah (11475727), Qi-Ming Deng (11475718), Ruqayya Rizvi (11475715), Wenkang Shang (4689595), Richard Mprah (11475721), Gabriel Komla Adzika (11475706), Adebayo Oluwafemi Adekunle (11475712), Marie Louise Ndzie Noah (11475724), Hongjian Hou (11475709)   +10 more
core   +1 more source