Results 201 to 210 of about 6,111,093 (245)

Emerging insights into amino acid metabolism in the heart: implications for cardiovascular diseases and therapeutic targeting

British Journal of Pharmacology, EarlyView.
As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam, Hongyuan Zhang, Min Zi, Chen Chen, Junfang Wu, Andreas Papapetropoulos, Xin Wang   +6 more
wiley   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

MD‐1 Deficiency Mitigates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation via cGAS‐STING Dependent Pathway in Macrophages

Cell Proliferation, EarlyView.
MD‐1 is induced and activated in macrophages. The activated MD‐1 subsequently promotes the cGAS‐STING‐TBK1‐IRF3 signalling pathway to activate the NLRP3 inflammasome, and subsequently increases pro‐inflammatory macrophage polarisation and decreases plaque stability to accelerate the development of atherosclerosis.
Fang Zhao, Zhili Jin, Zhiwei Cai, Quan Zhang, Tao He, Xiangjie Kong, Ming Chen, Zhibing Lu, Xiaorong Hu, Wen‐Lin Cheng   +9 more
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

RCC1 neuropathy mimics childhood axonal Guillain–Barré syndrome with variable clinical severity and survival

Developmental Medicine &Child Neurology, EarlyView.
We present 10 patients who presented with acute onset axonal neuropathy following infection, mimicking childhood axonal Guillain–Barré syndrome. We review phenotypes, undertake survival analysis, and assess function of novel RCC1 variants in vitro. Abstract Aim To assess the phenotype and genotype of 10 new patients with biallelic RCC1 variants who ...
Han Zhang, Beril Din, John H. McDermott, RCC1 Neuropathy Study Group, Adam Jackson, Halil Tuna Akar, Ali Dursun, Riza Koksal‐Ozgul, Reza Sadjadi, Lauren Politica, Stephan Zuchner, Reza Maroofian, Usman Ali, Dudu Turkyilmaz, Jawadur Rahman, Hasan Bas, Khalid Hussain, Khalid A Fakhro, Aljazi Al‐Maraghi, Annemarie CS Knijnenburg, Monique Engel, Debby Hellebrekers, Heike Losch, Sietse M Aukema, Marlene Kullik, Christoph Geier, Raymond T. O'Keefe, William G. Newman, J. Robert Harkness   +28 more
wiley   +1 more source

Cardiovascular complications during equine anaesthesia: From pre‐anaesthetic assessment to recovery

Equine Veterinary Education, EarlyView.
Summary Cardiac leiomyosarcoma is an exceptionally rare neoplasm in equids. The case report by Carroll et al. (2026; Equine Veterinary Education, 38, e686) in the October issue describes a mule that suffered fatal cardiovascular collapse during recovery, with post‐mortem examination revealing a cardiac leiomyosarcoma and severe pericardial effusion ...
P. M. C. Tomás, L. F. Louro
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source