Results 71 to 80 of about 37,313 (281)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Wound treatment and pain management: a stressful time
International Wound Journal, 2012 This review and case study report considers the evidence to indicate that the progress of wound healing is negatively affected by the presence of stressors and in circumstances where patients are in pain. It considers the relationship between perceptions of pain, stress and delayed wound healing with a specific focus on guidance for clinical practice ...
Kyoichi, Matsuzaki, Dominic, Upton
openaire +3 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Syllable, accent, rhythm: typological and methodological considerations for teaching Spanish as a foreign language [PDF]
, 2012 El ritmo es una propiedad del habla relacionada con la organizacióntemporal de los sonidos en términos de agrupamiento. Las unidades desegmentación son específicas de cada lengua y emergen de propiedades fonológicastales como la estructura silábica, la ...
Lahoz, José
core +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Pauses and the temporal structure of speech [PDF]
, 1994 Natural-sounding speech synthesis requires close control over the temporal structure of the speech flow. This includes a full predictive scheme for the durational structure and in particuliar the prolongation of final syllables of lexemes as well as for ...
Zellner, Brigitte
core +1 more source
Perceptual adjustment to time-compressed Speech: a cross-linguistic study [PDF]
, 1998 revious research has shown that, when hearers listen to artificially speeded speech, their performance improves over the course of 10-15 sentences, as if their perceptual system was "adapting" to these fast rates of speech.
Christophe, Anne +4 more
core +4 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Micronutrients against oxidative stress - time for clinical recommendations? [PDF]
Critical Care, 2012 Antioxidant micronutrient supplementation may be beneficial for critically ill patients. Often, cocktails of antioxidant micronutrients are used. Consequently, meta-analyses of available randomized controlled trials of antioxidant micronutrient supplementation are of particular interest.
openaire +2 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source