Results 71 to 80 of about 38,164 (261)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Perception of linguistic rhythm by newborn infants [PDF]
, 2000 Previous studies have shown that newborn infants are able to discriminate between certain languages, and it has been suggested that they do so by categorizing varieties of speech rhythm.
Ramus, Franck
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
, 2014 言語はリズムの型により分類され、強勢間の長さ、音節やモーラの長さがその基礎となると言われている。強弱や高さの違いにより形作られるリズムの等時性については議論が分かれるが、発話において等時性が観察されない場合でも、知覚においてそれが感知されるという説明もある。等時性を保つため、強勢リズム言語では第一ストレスの位置が移動し、もともと第二ストレスが置かれていた位置に収まるという現象がある。これは、リズムの衝突を避けるためのリズム規則と呼ばれている。実際の発話では、リズムの衝突を避け ...
TOMITA Kaoru
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The use of parametric tests in the study of vowel duration cue for voicing in the following word final consonant in Polish english [PDF]
, 1990 Chapter TenZadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 zostało dofinansowane ze środków MNiSW w ramach działalności ...
Waniek-Klimczak, Ewa
core
, 2010 Within the last two years, the global economic crisis has prompted unprecedented change, with organizations traditionally considered as “solid”, crumbling and liquidating in front of incredulous stock brokers and global audiences (some examples include Fannie Mae, Freddie Mac and the Lehman Brother s Holding Inc.).
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Lenguas de compás acentual y lenguas de compás silábico: revisión teórica e implicaciones pedagógicas [PDF]
, 2000 In this paper the traditional rhythmic classification of stress-timed and syllable-timed languages has been revised by means of the analysis of syllable structure, vowel reduction, intersyllabic compression and the strength of the contrast between ...
Cuenca Villarín, María Heliodora
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