Results 231 to 240 of about 10,382,141 (339)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Transcriptomic analysis reveals the role of the molybdate transporter2 in mediating nitrate stress tolerance in tomato seedlings. [PDF]

BMC Plant Biol
Zhou X, Yu S, Tang L, Liu X, Lei Q, Yu L, Xiong Y, Ye D, Wang W, Cao K, He Z.   +10 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Integrated transcriptome-metabolome analysis reveals oleanolic acid as a central regulator of heat stress adaptation in Rhododendron moulmainense. [PDF]

BMC Plant Biol
Liu S, Zhang L, Bai Y, Zhuang P, Cai H, Peng J, Cai Z, Hu B, Mao X, Xie L.   +9 more
europepmc   +1 more source

Plane strain: the direct determination of stress

, 1920
S. D. Carothers
openalex   +1 more source

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

Molecular Oncology, EarlyView.
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley   +1 more source

Physiological and molecular responses of individual and combined drought and heat stress on early anthesis of maize (Zea mays L.). [PDF]

Sci Rep
Mandyal SS, Bhadraiah S, Singh A, Jha RK, Singh AK.   +4 more
europepmc   +1 more source

Discussion: “Three-Dimensional Solution for Stress Concentration Around a Circular Hole in a Plate of Arbitrary Thickness” (Sternberg, E., and Sadowsky, M. A., 1949, ASME J. Appl. Mech., 16, pp. 27–38) [PDF]

, 1950
M. M. Frocht
openalex   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Mechanical performance of buried pipe under traffic load-internal pressure coupling action: Experimental and numerical study. [PDF]

PLoS One
Shan C, Li W.
europepmc   +1 more source