Results 61 to 70 of about 5,060,804 (319)

Psychosocial stress experience and DNA methylation in humans - implications for stress-adaptation and -resilience [PDF]

open access: yes, 2014
: Background: Psychosocial stress, especially early in life, is a risk factor for mental disorders. Recent evidence suggests that stress-related changes in epigenetic patterns, including DNA methylation, could mediate this association. Aim: to examine a
Unternaehrer, Eva
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Parent-led stepped care for traumatised children: parental factors that predict treatment completion and response

open access: yesEuropean Journal of Psychotraumatology, 2023
Background: Stepped care cognitive behavioural therapy for children after trauma (SC-CBT-CT; aged 7–12 years) can help to increase access to evidence-based trauma treatments for children.
Else Merete Fagermoen   +3 more
doaj   +1 more source

Higher use of techniques studied and performance in melee combat produce a higher psychophysiological stress response [PDF]

open access: yes, 2018
We aimed to analyse the effectiveness of an operative training in soldiers' psychophysiological and melee combat performance. Nineteen soldiers performed a 50-hr training for 10 weeks. After training, they were divided into two groups: higher performance
Diaz Manzano, Montaña   +11 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Burnout and hypocortisolism – a matter of severity? A study on ACTH and cortisol responses to acute psychosocial stress

open access: yesFrontiers in Psychiatry, 2015
Background: Common consequences of long-term psychosocial stress are fatigue and burnout. It has been suggested that burnout could be associated with hypocortisolism, thus, inability to produce sufficient amounts of cortisol.
Anna-Karin eLennartsson   +5 more
doaj   +1 more source

A stress free model for residual stress assessment using thermoelastic stress analysis [PDF]

open access: yes, 2014
Thermoelastic Stress Analysis (TSA) has been proposed as a method of obtaining residual stresses. The results of a preliminary study demonstrated that when Al-2024 plate containing holes that were plastically deformed by cold expansion process to 2% and ...
Robinson, Andy   +5 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Catecholamines and stress proceedings of the International Symposium on Catecholamines and Stress, held in Bratislava, Czechoslovakia, July 27-30, 1975

open access: yes, 1976
Catecholamines and Stress covers the proceedings of the International Symposium on Catecholamines and Stress, held in Bratislava, Czechoslovakia on July 27-30 ...
International Symposium on Catecholamines and Stress <1975, Bratislava, Czechoslovakia>   +3 more
core  

The measurement and prevention of work stress: a literature review.

open access: yes, 2023
reservedNella prima parte dell’elaborato viene illustrato il quadro teorico dello stress, attraverso alcuni dei principali modelli teorici di riferimento (di Selye, Cooper, Karasek, Cox e Mackay e Van Harrison e Caplan), e i relativi riferimenti ...
CERON, LETIZIA
core  

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