Results 91 to 100 of about 6,447,976 (288)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Finite Element Simulation of a Steady-State Stress Distribution in a Four Stroke Compressed Natural Gas-Direct Injection Engine Cylinder Head [PDF]
, 2006 The main aim of this work is to predict the design performance based on the stress/strain and thermal stress behaviour of cylinder head under various operating conditions.
Abdullah, S. +2 more
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Application of Topology Optimization in Design of Stem Profile in Hip Implants Using Finite Element Method [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2018 Appropriate design of stem shape is an important factor in total hip replacement. It affects the attachment of the implant to the bone and the stability of the implant.
Mohammad Reza Niroomand +1 more
doaj
Stress–singularity analysis in space junctions of thin plates [PDF]
, 2000 The stress singularity in space junctions of thin linearly elastic isotropic plate elements with zero bending rigidities is investigated. The problem for an intersection of infinite wedge-shaped elements is considered first and the solution for each ...
Mikhailov, SE, Namestnikova, IV
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Mechanical characteristics of carbon fibre yacht masts [PDF]
, 1995 This paper provides a preliminary stress analysis of a carbon reinforced layered cylinder such as would be found in a yacht mast. The cylinder is subjected to a compressive load and both an analytical and numerical analysis of the resulting stress fields
Blicblau, A., Clements, D.
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
High temperature stress-strain analysis [PDF]
The objectives of the high-temperature structures program are threefold: to assist in the development of analytical tools needed to improve design analyses and procedures for the efficient and accurate prediction of the nonlinear structural response of ...
Moorhead, Paul E., Thompson, Robert L.
core +1 more source