Results 101 to 110 of about 6,476,644 (264)
Nihon Kikai Gakkai ronbunshu, 2019 To design economical frame structures, it is necessary to determine the optimum frame layout and optimum cross-sectional area of each frame member. Although previous studies have proposed a variety of optimization methods, they can be applicable to small-
Eiji MURAKAMI +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
On the Behavior of Bauxite Tailings under a Wide Range of Stresses
MiningDespite its vital importance to the contemporary economy, some drawbacks are mainly associated with waste derived from mining activity. This waste consists of tailings that are hydraulically disposed of in large impoundments, the tailings dams.
Rosanne Rodrigues Santos Maciel Gonçalves +5 more
doaj +1 more source
Modular Rotor Single Phase Field Excited Flux Switching Machine with Non-Overlapped Windings
Energies, 2019 This paper aims to propose and compare three new structures of single-phase field excited flux switching machine for pedestal fan application. Conventional six-slot/three-pole salient rotor design has better performance in terms of torque, whilst also ...
Lutf Ur Rahman +7 more
doaj +1 more source
A study on task difficulty and acceleration stress [PDF]
, 1981 The results of two experiments which relate to task difficulty and the effects of environmental stress on tracking performance are discussed and compared to subjective evaluations.
Repperger, D. W., Rogers, D. B.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Dynamic Stress Analysis with Different boundry Conditions by ISO-Surface behaviour [PDF]
, 2015 Any CAE (Computer Aided Engineering) software the first result will be in contour manner which comes with the colour scale (Legend).But that will only give rough scenario about what is happening inside the layers in object when force is applied.
Pandya, P. K. (Parth) +1 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Analysis of silicon stress/strain relationships [PDF]
In the study of stress-strain relationships in silicon ribbon, numerous solutions were calculated for stresses, strain rates, and dislocation densities through the use of the Sumino model. It was concluded that many cases of failure of computer solutions
Dillon, O.
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source