Results 151 to 160 of about 6,447,976 (288)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A multi-modal wearable dataset for cognitive attention and task-based stress analysis. [PDF]

Data Brief
Motin MA, Ali MS, Bipro SS, Nuha MJ, Hasan A, Kabir S.   +5 more
europepmc   +1 more source

March 1971 wind tunnel tests of the Dorand DH 2011 jet flap motor, volume 2 [PDF]

Wind tunnel tests were conducted of the Dorand DH 2011D jet flap rotor. The data recorded during the tests consist of: (1) multicyclic cam coefficients, (2) stress analysis, (3) vibratory loads, (4) Fourier analysis of flap deflection, and (5) blade ...
Aubrun, J., Kretz, M., Larche, M.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Quantitative Residual Stress Analysis in Steel Structures Using EMAT Nonlinear Acoustics. [PDF]

Sensors (Basel)
Balasubramaniam K, Ortiz BN, Bejarano ÁP.   +2 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Design and Interlaminar Stress Analysis of Composite Fan Blade Shank. [PDF]

Polymers (Basel)
Wu Y, Zhang Y, Wang Z, Jin L, Tang X, Li X, Chen Y.   +6 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Vibrational Stress Analysis and Test Verification of Satellite Honeycomb Sandwich Plate Subjected to Acoustic Excitation. [PDF]

Sensors (Basel)
Zhang L, Shi Y, Chen S, Zhao X, Yu J, Zhang L.   +5 more
europepmc   +1 more source

Thermal Stress Analysis and Control Method for Surface Acoustic Wave Atomizer. [PDF]

Sensors (Basel), 2023
Xue X, Cui B, Chen X, Wang W, Sun M, Liang Y.   +5 more
europepmc   +1 more source