Results 161 to 170 of about 793,809 (264)

Polypharmacology of Pathway Crosstalk in Neurodegenerative Diseases: Chemical Modulation of Interconnected Signaling Networks. [PDF]

Cells
Khan MS, Zafar I, Noman M, Yang G, Kang KS, Bopassa JC.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Decoding spontaneous intracerebral hemorrhage: mechanistic breakthroughs and disruptive revolution in pharmacological treatment. [PDF]

Exp Mol Med
Chen Y, Wu G, Zhang W, Zou Z, Huang L, Shi H, Wang Q, Chen W, Luo Z, Zhao Z, Wu L, Li Z, Peng J, Chen Y, Zhang JH.   +14 more
europepmc   +1 more source

An approach for shear-stress based scour prediction

, 2019
Ryan Coe, Alice Gillespie, Chris Chartrand, Mike Morrow, Mike Delos-Reyes, Fabian Wendt, Yi-Hsiang Yu, Tuba Oskan-Haller, Pedro Lomanaco, Jesse Roberts, Sterling Olson, Craig Jones   +11 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Warpage of Injection-Moulded Thin Plates: Numerical Evaluation of Simulation Strategies and Experimental Validation. [PDF]

Polymers (Basel)
Kastelic T, Mole N, Cafuta G, Starman B, Halilovič M.   +4 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Modern genomic and omics-based technologies for millet breeding and genetic improvement. [PDF]

Front Plant Sci
Kumar A, Muthuramalingam P, Verma L, Kumar R, Kumar N, Misra J, Ravi K, Shin H, Ramesh M.   +8 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Bridging scales: integrated multi-omics and deep phenotyping for climate resilience in crop plants. [PDF]

Front Plant Sci
Anand S, Reddy SB, Shajini NM, Jose E, Shirsat MS, Visakh RL, Jha UC, Sah RP, Beena R.   +8 more
europepmc   +1 more source