Results 141 to 150 of about 10,094,478 (315)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

A Study of Parenting Stress in Parents of Children with Disabilities

, 2009
[[abstract]]Abstract The purpose of this research was to explore potential predictors of parenting stress in parents of children with disabilities. Further understanding of parenting stress in parents of children with disabilities may assist to provide ...
Change Yu Rung
core  

Change trajectory and influencing factors of stress response in newly diagnosed AIDS patients

Huli yanjiu
ObjectiveTo explore the longitudinal change trajectory of stress response of newly diagnosed AIDS patients and to analyze its influencing factors.MethodsUsing convenience sampling method,a total of 116 newly diagnosed AIDS patients in a tertiary grade A ...
HUANG Wenting, HE Huamei, MO Xiaoyun, QIN Xiaojie, HUANG Aili, WANG Fang   +5 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Climate and Global Change Interagency Inventory Data Sheet

, 2002
The Climate and Global Change Interagency Inventory Data Sheet is a working document (dated August 2002) that includes information provided by federal agencies regarding their climate and global change research ...
Climate Change Science Program
core  

Sun Protection as a Strategy for Managing Heat Stress in Avocado Trees

The increasing incidence of heat stress due to global climate change poses a significant challenge to avocado (Persea americana) cultivation, particularly in regions with intense solar radiation.
Marcelo de Souza Silva, Ono, Elizabeth Orika [UNESP], Elizabeth Orika Ono, Débora Cavalcante dos Santos Carneiro, Rodrigues, João Domingos [UNESP], Carneiro, Débora Cavalcante dos Santos [UNESP], João Domingos Rodrigues, Leonel, Sarita [UNESP], Silva, Marcelo de Souza [UNESP], Adilson Pimentel Junior, Marco Antonio Tecchio, Tecchio, Marco Antonio [UNESP], Sarita Leonel, Pimentel Junior, Adilson [UNESP], Francisco José Domingues Neto, Domingues Neto, Francisco José [UNESP]   +15 more
core   +1 more source