Results 41 to 50 of about 286,701 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Research On Globe-cone Joint Assembly Of Spacecraft Propulsion System

MATEC Web of Conferences, 2017
As one of the key step of spacecraft propulsion system assembly, globe-cone joint assembly determines the spacecraft’s high reliability and long life on orbit. Through test, simulation analysis and calculation on sealing mechanism of globe-cone joint, in
Zhang Yanlei, Zhang Feikai, Bian Yuchuan, Fan Yougao, Xu Kai   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Buckling behavior of AA6061 circular tube under axial compression by considering contact condition of tube end

International Journal of Lightweight Materials and Manufacture, 2021
When a circular tube is under axial compression, it can be developed into specific forming technologies (e.g., tube inversion). However buckling failure is prone to occurring and seriously restricts the successful realization of the forming process or ...
Zhi-chao Sun, Jing Cao, Long Huang, Zhi-kun Yin, Li-shuang Zheng   +4 more
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Seal-surface Contact Stress Analysis of the Connection under Tension-compression Alternating Load

Shiyou jixie, 2018
To select proper gas-seal connection of injection-production casing string under tension-compression alternating loads, based on the nonlinear theory of elastoplastic contact, the finite element analysis method is used to investigate the distribution of ...
Wang Jianjun, Sun Jianhua, Gao Jinwei, Yang Shangyu   +3 more
doaj  

STUDY ON INTERFERENCE INSTALLATION OF HYDRAULIC KEYLESS SLEEVE COUPLING FOR A SHIP’S TAIL SHAFT

Jixie qiangdu, 2021
Absrtact Aiming at the safety problem of the hydraulic keyless sleeve coupling caused by the increase of bearing power of a ship’s CPP,studied the interference installation of coupling sleeve-cone sleeve-tail shaft for transferring torque and thrust ...
ZHANG QingJu, WANG DeLun, ZHANG YuNing, WANG LiHua   +3 more
doaj  

Wall slip and flow of concentrated hard-sphere colloidal suspensions

, 2012
We present a comprehensive study of the slip and flow of concentrated colloidal suspensions using cone-plate rheometry and simultaneous confocal imaging.
Barrett K. E. J., G. Petekidis, Hunter R. J., L. Isa, Larson R. G., Lee B., P. Ballesta, R. Besseling, W. C. K. Poon   +8 more
core   +1 more source

PBF‐LB/M of Ti‐6Al‐4V: High‐Pressure Solution Treatment and Aging for Applications in a Sustainable Aerospace

Advanced Engineering Materials, EarlyView.
Additive manufacturing (AM) allows great geometric freedom for lightweight components. As parts are progressively optimized exploiting potentials in AM leading in smaller material cross sections, high pressure solution treating and aging (STA) treatments show an enormous potential for strongly improving material properties.
Mika León Altmann, Andre Danzig, Freerk Syassen, Rainer Fechte‐Heinen, Anastasiya Toenjes   +4 more
wiley   +1 more source