Results 41 to 50 of about 4,924,273 (328)

Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency

open access: yesJournal of Biological Chemistry, 2017
Endoplasmic reticulum (ER) stress and mislocalization of improperly folded proteins have been shown to contribute to photoreceptor death in models of inherited retinal degenerative diseases.
Michael R. Butler   +10 more
semanticscholar   +1 more source

ATF6 is essential for human cone photoreceptor development

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2021
Significance Inactivating genetic variants in the Unfolded Protein Response (UPR) regulator Activating Transcription Factor 6 (ATF6) result in loss of color vision, which is linked to dysfunctional cone photoreceptors and the development of achromatopsia.
H. Kroeger   +13 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Numerical evidence for the Maldacena conjecture in two-dimensional N=(8,8) super Yang-Mills theory

open access: yes, 2005
The N=(8,8) super Yang-Mills theory in 1+1 dimensions is solved at strong coupling to directly confirm the predictions of supergravity at weak coupling.
Antonuccio   +12 more
core   +2 more sources

X-ray residual stress measurements on cold-drawn steel wire [PDF]

open access: yes, 1982
The interplanar spacing d{hkl} versus sin2 ψ distributions were measured for the 211, 310, 220 and 200 reflections from severely cold-drawn 0.7% C steel wire with a diameter of 0.25 mm. From the shape of the curves it was concluded that, as well as a 110
Naughton, B.P.   +2 more
core   +4 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

A Sophisticated Method of the Mechanical Design of Cable Accessories Focusing on Interface Contact Pressure

open access: yesEnergies, 2020
The most critical positions of a prefabricated cable accessory, from the electrical point of view, are the interfaces between the stress cone and its surroundings.
Yi Luo   +3 more
doaj   +1 more source

Three-Dimension Crack Propagation Behavior of Conical-Cylindrical Shell

open access: yesMetals, 2023
The conical-cylindrical shell is prone to stress concentration in the convex cone position under the action of deep-sea pressures. This results in unidirectional or bidirectional positive tensile stresses on the surfaces of the shell.
Yongmei Zhu, Jiahao Yang, Hongzhang Pan
doaj   +1 more source

Conical defects in growing sheets

open access: yes, 2008
A growing or shrinking disc will adopt a conical shape, its intrinsic geometry characterized by a surplus angle $se$ at the apex. If growth is slow, the cone will find its equilibrium. Whereas this is trivial if $se
D. Fuchs   +8 more
core   +1 more source

SYM Correlators and the Maldacena Conjecture [PDF]

open access: yes, 2002
We report on progress in evaluating quantum filed theories with supersymmetric discrete light-cone quantization (SDLCQ). We compare the method to lattice gauge theory and point out its relevance for lattice calculations.
Campostrini   +12 more
core   +2 more sources

Home - About - Disclaimer - Privacy