Results 61 to 70 of about 68,365 (261)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Simulation Method for Complex Constraints and the Necessity of Joints in an Early-Age, Large-Volume Concrete Slab—A Case Study of Complex Column Grids and Wall Constraints

Buildings
In modern engineering and construction, mass concrete structures impose stringent requirements on crack control. However, there exists a conflict between design and construction: design primarily addresses the structural performance needs during service ...
Wenqian Li, Wei Jiang, Chen Fu, Zhiyi Li, Hao Zhang   +4 more
doaj   +1 more source

Geometry and Material Constraint Effects on Creep Crack Growth Behavior in Welded Joints

High Temperature Materials and Processes, 2017
In this work, the geometry and material constraint effects on creep crack growth (CCG) and behavior in welded joints were investigated. The CCG paths and rates of two kinds of specimen geometry (C(T) and M(T)) with initial cracks located at soft HAZ ...
Li Y., Wang G. Z., Xuan F. Z., Tu S. T.
doaj   +1 more source

Thermal Strain Detection for Concrete Structure Cold Shrinkage under Stress Constraint with FBG. [PDF]

Sensors (Basel), 2022
Yang L, Li C, Luo C.
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Influence of boundary condition and stiffener type on collapse behaviours of stiffened panels under longitudinal compression

Advances in Mechanical Engineering, 2019
A series of stiffened panels with different dimensions and types of stiffener are simulated under longitudinal compression in finite element code ANSYS.
Jin Pan, Na Li, Zhao Jun Song, Ming Cai Xu   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Study on Thermo-Mechanical Coupling Characteristics of Crack Initiation and Propagation at Precast–Cast-in-Place Concrete Interface of Bridges Under High Temperature

Advances in Civil Engineering
To reveal the initiation and propagation mechanism of cracks at the precast–cast-in-place concrete interface of bridges in high-temperature environments, an analytical model of interfacial cracks considering the thermo-mechanical coupling effect is ...
Chengyou Xiao, Jianhua Wang, Hao Chen, Dong Tan   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Abiotic Stress: A Constraint in Farming

International Journal of Current Microbiology and Applied Sciences, 2021
Gummadi Shirisha Harmeet Singh Janeja, Alla Rahul Reddy   +1 more
openaire   +1 more source