Results 111 to 120 of about 5,252,193 (310)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Dual Cohort Insights Into Accelerometer‐Derived Weekend Warrior Physical Activity and Its Impact on Mortality

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Although guidelines on physical activity recommend at least 150 minutes of moderate‐to‐vigorous exercise weekly for optimal health outcomes, the distinction between concentrated and evenly distributed activity patterns remains unclear.
Rui Ren, Wenxu Wang, Qitong Liu, Xingyue Ye, Linze Xi, Ru Zhang, Liying Wang, Yao Zhang, Yanan Ma, Difei Wang   +9 more
doaj   +1 more source

Residual Stress Control Using Process Optimization in Directed Energy Deposition. [PDF]

Materials (Basel), 2023
Cheng M, Zou X, Pan Y, Zhou Y, Liu W, Song L.   +5 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin

Antioxidants
Hydrogen peroxide (H2O2) plays a crucial role in cell signaling in response to physiological and environmental perturbations. H2O2 can oxidize typical 2-Cys peroxiredoxin (PRX) first into a sulfenic acid, which resolves into a disulfide that can be ...
Shengnan Liu, Jingbo Pi, Qiang Zhang
doaj   +1 more source

Stress control as a method to reduce perceived pain in oral lichen planus. [PDF]

Postepy Dermatol Alergol, 2023
Szymczak-Paluch M, Kłosek S.
europepmc   +1 more source

Method for Particle Size Control During the Drying and Granulation in Fluidized Bed [PDF]

, 2001
The fluidized bed process presented in this paper is suitable for recovery of solids from solutions in the form of granules. The solution is sprayed into the bed and as solvent evaporates, solid material is deposited on the surface of fluidizing ...
Dencs, B., Gyenis, János, Tardos, I. G.
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Tumor necrosis factor mediates the impact of PM2.5 on bone mineral density: Inflammatory proteome Mendelian randomization and colocalization analyses

Ecotoxicology and Environmental Safety
To assess the causal effect of particulate matter 2.5 (PM2.5) on human bone mineral density (BMD) and to explore the possible mechanism and proportion mediated by inflammation-related protein.
Mingzheng Li, Peng Shi, Huajie Yang, Suyuan Tong, Nianfeng Qiu, Fan Yao, Yuan Du, Shuhua Xi, Fei Wang   +8 more
doaj   +1 more source

Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration. [PDF]

EMBO Mol Med, 2023
Shirakura K, Baluk P, Nottebaum AF, Ipe U, Peters KG, McDonald DM, Vestweber D.   +6 more
europepmc   +1 more source