Results 31 to 40 of about 2,006,397 (268)
Neurological complications of diabetes mellitus
Медицинский совет, 2019 Diabetes mellitus (DM) seriously and negatively affects the physical, mental and social well-being of patients. Among the complications of DM, neurological complications associated with both central and peripheral nervous system lesions are of great ...
O. V. Kotova +2 more
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Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Cardiac autonomic neuropathy in diabetic patients
Медицинский совет, 2019 Cardiac autonomic neuropathy (CAN) is a common and insufficiently diagnosed complication of diabetes mellitus. This is usually due to the fact that the disease runs asymptomatically until the very late stages.
A. A. Belyaev +2 more
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Neural control of chronic stress adaptation [PDF]
Frontiers in Behavioral Neuroscience, 2013 Stress initiates adaptive processes that allow the organism to physiologically cope with prolonged or intermittent exposure to real or perceived threats. A major component of this response is repeated activation of glucocorticoid secretion by the hypothalamo-pituitary-adrenocortical (HPA) axis, which promotes redistribution of energy in a wide range of
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Journal of Experimental & Clinical Cancer ResearchBackground Activator protein-1 (AP-1) represents a transcription factor family that has garnered growing attention for its extensive involvement in tumor biology.
Hongchao Zhang +7 more
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Proteotoxic Stress and Cell Lifespan Control
Molecules and Cells, 2008 Eukaryotic cells continuously integrate intrinsic and extrinsic signals to adapt to the environment. When exposed to stressful conditions, cells activate compartment-specific adaptive responses. If these are insufficient, apoptosis ensues as an organismal defense line.
CENCI S, PENGO N, SITIA , ROBERTO
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Trimebutine maleate in the treatment of functional biliary disorders: TRIBUNE study results
Медицинский совет, 2019 Introduction. The term «functional disorders of the biliary tract and bile ducts» defines the conditions, which produce typical patterns of biliary pains in the absence of obvious signs of organic lesions of the gallbladder and bile ducts.
V. T. Ivashkin +3 more
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Stress and the Control of Apoptosis [PDF]
The Scientific World JOURNAL, 2001 Apoptotic cell death is coordinated by the caspase proteases, and these are activated via two major pathways. One of these depends upon the binding of death receptors, such as Fas (CD95) by their ligands. Alternatively, apoptosis can proceed by the activation of pro-apoptotic Bcl-2 family proteins that induce a permeabilization of the mitochondrial ...
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