Results 71 to 80 of about 5,252,193 (310)

Stress control and bicuspidization

International Journal Of Community Medicine And Public Health, 2023
Mandibular molars being the first teeth to erupt in the oral cavity have high caries susceptibility index, deprivation in its maintenance may lead to serious problem like furcation involvement. Recent advances in dentistry and the desire of patients to maintain their dentition, have lead to treatment of teeth that once would have been removed ...
W. Priya Devi, Babina Chirom, Tharaina Mushahary   +2 more
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]

, 2016
Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F., Aliaga, E., Díaz-Véliz, G., Fiedler, J.L., Fresno, C., García-Rojo, G., Mora, S., Pacheco, A., Parra, C.S., Parra-Fiedler, N., Rojas, P.S., Tejos, M., Vilches, N.   +12 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress. [PDF]

, 2018
BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood.
Aschbacher, Kirstin, Burelle, Yan, Coccia, Michael, Cuillerier, Alexanne, Epel, Elissa S, Picard, Martin, Prather, Aric A, Puterman, Eli   +7 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Neurotropic B vitamins: analgesic and anti-inflammatory effects

Клинический разбор в общей медицине, 2020
Patients with musculoskeletal diseases (MSDs) constitute a heavy burden on the society. Therefore, there is a constant search for safe and efficient methods for treatment of such conditions, in which inflammation underlies the pathogenetic process ...
Anton A. Beliaev, Olga V. Kotova , Elena S. Akarachkova   +2 more
doaj   +1 more source

On the impact of capillarity for strength at the nanoscale

, 2017
The interior of nanoscale crystals experiences stress that compensates the capillary forces and that can be large, in the order of 1 GPa. Various studies have speculated on whether and how this surface-induced stress affects the stability and plasticity ...
Mameka, Nadiia, Markmann, Jürgen, Weissmüller, Jörg   +2 more
core   +2 more sources

Attentional biases for food stimuli in external eaters: Possible mechanism for stress-induced eating? [PDF]

, 2008
External eaters reportedly increase snack intake when stressed, which could be due to an attentional shift towards food stimuli. Attentional biases for food stimuli were tested in high and low external eaters in stress and control conditions, using a ...
Boon, Broschott, Conner, Daryl B. O’Connor, Davidson, Emily Newman, Faunce, Greeno, Heatherton, Heatherton, Johansson, Leech, Mark Conner, Marteau, Mogg, Newman, Oliver, Overduin, O’Connor, O’Connor, Schachter, Smith, Stroop, Thorndike, Van Strien   +24 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source