Results 131 to 140 of about 5,046,540 (331)

Generation of Finite Life Distributional Goodman Diagrams for Reliability Prediction

open access: yes, 1971
The methodology of developing finite life distributional Goodman diagrams and surfaces is described for presenting allowable combinations of alternating stress and mean stress to the design engineer.
Guerrieri, W. N., Kececioglu, D.
core  

PVP2008-61404 STUDY ON STRESS-STRAIN RELATION FOR TYPE 316L STAINLESS STEEL USING MIXED HARDENING LAW

open access: yes, 2020
To determine stress-strain diagrams for a pipe butt joint of type 316L stainless steel, stress-strain diagrams for pipe specimens subjected to monotonic uniaxial tensile load were measured.
Nobuyoshi Yanagida
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Comparison, GO annotation and Fisher's exact test of differentially expressed transcripts under stress and post-stress.

open access: yes, 2012
[A] Venn diagrams of the differentially expressed transcripts in cross-cultivar microarray comparisons. The Venn diagrams show the number of overlapping and non-overlapping transcripts with significantly differential expression between stress and post ...
Panagiotis Kalaitzis (140387)   +6 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

The usage of complete stress-strain softening diagrams for an estimation of limiting damage of material under complex modes loading

open access: yes, 2009
На конкретних прикладах показано переваги методу повних діаграм деформування для оцінки граничної пошкодженості матеріалу при складних режимах навантаження.
Пилипенко, А.   +3 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The Application of Empirical Phase Diagrams to the Biophysical Characterization and Stabilization of Viral Vaccine Candidates [PDF]

open access: yes, 2010
This dissertation describes the application of a composite biophysical approach to the characterization and stabilization of viruses and virus-like particles for vaccine purposes.
Kissmann, Julian Michael
core  

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