Results 261 to 270 of about 355,414 (304)

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

open access: yesExploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

Alpha‐Lipoic Acid Alleviates Isoflurane‐Induced Cognitive Dysfunction in Juvenile Mice by Activating Peroxisome Proliferator Activated Receptor Gamma Coactivator ‐1 Alpha

open access: yesFood Frontiers, EarlyView.
Alpha‐lipoic acid (ALA) plays a significant role in alleviating isoflurane‐induced cognitive dysfunction in juvenile mice by activating PGC‐1α, which improves mitochondrial function and energy metabolism in astrocytes. As a potent antioxidant, ALA is commonly found in foods like spinach, broccoli, and yeast, and its supplementation may offer ...
Xingkai Zhao   +4 more
wiley   +1 more source

Exploring the application of ferroelectret nanogenerators in medical engineering

open access: yesFlexMat, EarlyView.
Abstract Flexible devices derived from piezoelectric materials have gained considerable attention due to their exceptional biocompatibility. Among these, ferroelectret nanogenerators (FENG) is a novel type of flexible piezoelectric device that integrates self‐powering, actuation, and sensing capabilities.
Xianfa Cai   +4 more
wiley   +1 more source

Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology

open access: yesGlia, EarlyView.
In a pre‐symptomatic mouse model of Alzheimer disease, despite higher amyloid‐β load, females display fewer plaques than males. More efficient synaptic transmission as well as less microgliosis point to better early coping with pathogenesis in females.
Thomas Chaigneau   +7 more
wiley   +1 more source

Demographic Disparities in Diagnosis and Treatment of Anxiety and Depressive Disorders in Head and Neck Cancer Survivors

open access: yesHead &Neck, EarlyView.
ABSTRACT Background The associations between head and neck cancer (HNC) and anxiety and depression are well‐known, but knowledge regarding the association between demographic factors and rates of diagnosis and treatment for these disorders among HNC survivors is incomplete.
Tyler J. Gallagher   +4 more
wiley   +1 more source

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