Results 61 to 70 of about 813,784 (293)

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Design, implementation, and evaluation of Youth Peer Support Training to improve quality of life and stress among homebound and bedridden older adults [PDF]

Journal of Research Development in Nursing and Midwifery, 2023
Background: Health care provided by youth can support homebound and bedridden older adults. The purpose of this study was to develop a program for homebound and bedridden older adults in rural areas of northeastern Thailand. Methods: The methodology was
Boonyada Wongpiomoln, Chanidawadee Sayuen, Ladda Pholputta, Nitchapanrawee Phengphol   +3 more
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Psychological distress and coping in military cadre candidates

Neuropsychiatric Disease and Treatment, 2016
Can Nakkas,1 Hubert Annen,1 Serge Brand2,3 1Department of Military Psychology Studies, Military Academy at ETH Zurich, Zurich, 2Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders, 3Department of Sport ...
Nakkas C, Annen H, Brand S
doaj  

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The current state of physical activity and exercise programs in German-speaking, Swiss psychiatric hospitals: results from a brief online survey

Neuropsychiatric Disease and Treatment, 2016
Serge Brand, 1,2 Flora Colledge, 2 Nadja Beeler, 2 Uwe Pühse, 2 Nadeem Kalak, 1 Dena Sadeghi Bahmani, 1 Thorsten Mikoteit, 1 Edith Holsboer-Trachsler, 1 Markus Gerber 2 1Psychiatric Clinics of the University of Basel, Center for Affective ...
Brand S, Colledge F, Beeler N, Pühse U, Kalak N, Sadeghi Bahmani D, Mikoteit T, Holsboer-Trachsler E, Gerber M   +8 more
doaj  

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Exercise is medicine for patients with major depressive disorders : but only if the “pill” is taken!

Neuropsychiatric Disease and Treatment, 2016
Markus Gerber,1 Edith Holsboer-Trachsler,2 Uwe Pühse,3 Serge Brand1,2 1Department of Sport, Exercise and Health, Division of Sport and Psychosocial Health, University of Basel, 2Center for Affective, Stress and Sleep Disorders, Psychiatric ...
Gerber M, Holsboer-Trachsler E, Pühse U, Brand S   +3 more
doaj  

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source