Results 61 to 70 of about 4,796,702 (301)

Stress in healthy young women : psychophysiological stress response and sleep in the context of adverse childhood experiences and daily stress [PDF]

, 2014
The aim of the present dissertation is to contribute to the knowledge about different aspects of stress and their impact on healthy young women. The relationship between daily stress, presleep arousal, and sleep was investigated and additionally, the ...
Winzeler, Katja
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Childhood psychopathology in children of women with eating disorders: understanding risk mechanisms. [PDF]

, 2014
Very few studies have investigated psychopathology in children of mothers with eating disorders (ED). We aimed to determine the effect of maternal ED on childhood psychopathology in a large population-based cohort and investigate relevant risk pathways ...
Simonoff, Emily, Micali, N, Stahl, Daniel; id_orcid, Treasure, Janet; id_orcid, Stahl, Daniel, Micali, Nadia, Simonoff, E, Simonoff, Emily; id_orcid, Stahl, D, Treasure, Janet, Treasure, J   +10 more
core   +1 more source

Oxidative Stress and Psychiatric Disorders: Evidence from the Bidirectional Mendelian Randomization Study

, 2022
Observational studies have shown that oxidative stress is highly related to psychiatric disorders, while its cause–effect remains unclear. To this end, a Mendelian randomization study was performed to investigate the causal relationship between oxidative
Feng, Xiaoyang, Sun, Yaoyao, Yundan Liao, Weihua Yue, Kang, Zhewei, Lu, Zhe, Zhe Lu, Yaoyao Sun, Zhang, Yuyanan, Yuyanan Zhang, Yue, Weihua, Liao, Yundan, Pu, Chengcheng, Zhewei Kang, Xiaoyang Feng, Chengcheng Pu   +15 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Acute Bouts of Exercising Improved Mood, Rumination and Social Interaction in Inpatients With Mental Disorders

Frontiers in Psychology, 2018
Background: Studies at the macro level (such as longer-term interventions) showed that physical activity impacts positively on cognitive-emotional processes of patients with mental disorders.
Serge Brand, Serge Brand, Serge Brand, Flora Colledge, Sebastian Ludyga, Raphael Emmenegger, Nadeem Kalak, Dena Sadeghi Bahmani, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Uwe Pühse, Markus Gerber   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Examining Dark Triad traits in relation to mental toughness and physical activity in young adults

Neuropsychiatric Disease and Treatment, 2016
Sarah Sabouri,1 Markus Gerber,2 Dena Sadeghi Bahmani,3 Sakari Lemola,4 Peter J Clough,5 Nadeem Kalak,3 Mahin Shamsi,1 Edith Holsboer-Trachsler,3 Serge Brand2,3 1Faculty of Educational Sciences and Psychology, AllamehTabataba’i University ...
Sabouri S, Gerber M, Sadeghi Bahmani D, Lemola S, Clough PJ, Kalak N, Shamsi M, Holsboer-Trachsler E, Brand S   +8 more
doaj  

Efficacy and safety of intravenously applied caffeine augmentation in electroconvulsive therapy

Neuroscience Applied
Electroconvulsive therapy (ECT) is a neuromodulation procedure that uses short electrical pulses causing a brief generalized seizure to treat depression, mania, schizophrenia, and catatonia.
Magdalena D. Ridder, Sarah Ulrich, Richard Vettermann, Timur Liwinski, Gunnar Deuring, Jan Sarlon, Annette Brühl, Else Schneider   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source