Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Nonlinear Stress Fluctuation Dynamics of Sheared Disordered Wet Foam
Sheared wet foam, which stores elastic energy in bubble deformations, relaxes stress through bubble rearrangements. The intermittency of bubble rearrangements in foam leads to effectively stochastic drops in stress that are followed by periods of elastic
A.A. Kader +21 more
core +1 more source
Mechanical noise dependent Aging and Shear Banding behavior of a mesoscopic model of amorphous plasticity [PDF]
We discuss aging and localization in a simple "Eshelby" mesoscopic model of amorphous plasticity. Plastic deformation is assumed to occur through a series of local reorganizations.
Roux, Stéphane, Vandembroucq, Damien
core +5 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Probability Distributions for Quantum Stress Tensors Measured in a Finite Time Interval
A meaningful probability distribution for measurements of a quantum stress tensor operator can only be obtained if the operator is averaged in time or in spacetime. This averaging can be regarded as a description of the measurement process.
Fewster, Christopher J., Ford, L. H.
core +1 more source
The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
The failure probabilities or the strength distributions of heterogeneous 1D systems with continuous local strength distribution and local load sharing have been studied using a simple, exact, recursive method.
B. Kahng +9 more
core +1 more source
Trolox and ascorbic acid reduce direct and indirect oxidative stress in the IPEC-J2 cells, an in vitro model for the porcine gastrointestinal tract [PDF]
Oxidative stress in the small intestinal epithelium is a major cause of barrier malfunction and failure to regenerate. This study presents a functional in vitro model using the porcine small intestinal epithelial cell line IPEC-J2 to examine the effects ...
De Smet, Stefaan +7 more
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Technical SWOT analysis of decentralised production for low voltage grids in Flanders [PDF]
The increasing energy prices, combined with high funding by the government, has resulted in a massive integration of decentralised electrical energy production units in Belgium.
Debruyne, Colin +3 more
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