Results 41 to 50 of about 81,100 (297)

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Quantitative Assessment of Myocardial Ischemia in Multi-Vessel Coronary Artery Disease by Multimodal Stress Echocardiography with Semi-Supine Bicycle Ergometry

Рациональная фармакотерапия в кардиологии, 2020
Stress echocardiography is a modern widely used method of noninvasive diagnosis of coronary heart disease and stratification of the risk of cardiovascular complications.
S. N. Koretskiy, O. M. Drapkina, F. B. Shukurov, D. K. Vasiliev   +3 more
doaj   +1 more source

Effects of anesthesia on conventional and speckle tracking echocardiographic parameters in a mouse model of pressure overload

, 2015
Genetically‑modified mice are widely applied in cardiovascular studies as model organisms. Echocardiography is a key tool for evaluating cardiac and hemodynamic functions in mice.
Wu, Xiaofen, Cao, Ming, Wang, Guan, Zhang, Le, Manyande, Anne, Wang, Jinli, He, Wei, Zhang, Cuntai   +7 more
core   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

The Clinical Utility and Enduring Versatility of Stress Echocardiography

, 2019
Stress echocardiography is an established cardiac imaging modality for the detection and quantification of severity of coronary artery disease. In recent years, there has also been an increasing use of stress echocardiography in the assessment of non ...
Quah, Jing Xian, Greaves, Kim, Thomas, Liza, Stanton, Tony   +3 more
core   +1 more source

Prognostic value of reduced heart rate reserve during exercise in hypertrophic cardiomyopathy [PDF]

, 2021
Background: Sympathetic dysfunction can be evaluated by heart rate reserve (HRR) with exercise test. Objectives: To determine the value of HRR in predicting outcome of patients with hypertrophic cardiomyopathy (HCM). Methods: We enrolled 917 HCM patients
Monserrat, Lorenzo, Luigi Tassetti, D'Alfonso, Maria Grazia, Varga, Albert, Attila Pálinkás, Alfonso, D Maria Grazia, Lopes, Luis, Tesic, Milorad, Lorenzoni, Valentina, Olivotto, I., Eugenio Picano, Luis Lopes, Bellagamba, Clarissa C.A., Pálinkás Dalma Eszter, Fabio Mori, Grazia Canciello, Tassetti Luigi, D'Alfonso, M. G., Ana Djordjevic-Dikic, Ágoston Gergely, Carlos Cotrim, Pálinkás, Attila, Pálinkás, Eszter, Olivotto Iacopo, Cortigiani, Lauro, Djordjevic-Dikic, Ana, Ciampi Quirino, Peteiro, Jesus, Milazzo Alessandra, Clarissa Bellagamba, Xusto Fernandez, Bellagamba, Clarissa, Quirino Ciampi, Caroline Van De Heyning, Pálinkás Attila, Carpeggiani, Clara, Losi, Mariangela, Lopes, Luis Rocha, Eszter Pálinkás, Palinkas, Eszter Dalma, Federica Re, Bruno Villari, Milazzo, Alessandra, Fernandez Xusto, Stress Echo 2020 Study Group on behalf of the Italian Society of of Echocardiography and Cardiovascular Imaging, Tassetti, Luigi, Olivotto, Iacopo, Albert Varga, D’Alfonso, Maria, Beleslin, Branko, Torres, Marco, Sepp Róbert, Tassetti, L., Clara Carpeggiani, Monserrat Lorenzo, Canciello, Grazia, Lorenzo Monserrat, Lauro Cortigiani, Milorad Tesic, Róbert Sepp, Sepp, Róbert, Jesus Peteiro, Cruz, Ines, Torres, Marco A.R., Villari, Bruno, Fernandez, Xusto, Varga Albert, Iacopo Olivotto, Maria D’Alfonso, Ciampi, Quirino, Gergely Ágoston, Van De Heyning, Caroline, Re, Federica, Picano, Eugenio, Sandro Betocchi, Branko Beleslin, Mori, F., Mori, Fabio, Marco Torres, Mariangela Losi, Milazzo, A., Cotrim, Carlos, Ágoston, Gergely, the Stress Echo 2020 Study Group on behalf of the Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI), Valentina Lorenzoni, Betocchi, Sandro, Ines Cruz, Mori Fabio, Peteiro Jesus, Alessandra Milazzo   +89 more
core   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Diagnostic Test Squatting Stress Echocardiography and Coronary Angiography in Diagnosing Coronary Heart Disease

Majalah Kardiologi Indonesia, 2017
Background: In patients with significant coronary heart disease (CHD), increased preload and afterload during a squat can cause wall motion abnormalities (WMA) which can be detected on echocardiography.
Andy Rahman, Mefri Yanni, Masrul Syafri
doaj   +1 more source

Diagnostic feature analysis of a dobutamine stress echocardiography dataset using rough sets

, 2008
Stress echocardiography is an important functional diagnostic and prognostic tool that is now routinely applied to evaluate the risk of cardiovascular artery disease (CAD).
Revett, K.
core   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source