Results 31 to 40 of about 224,688 (263)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Quantifying a stress gradient: An objective approach to variable selection, standardization and weighting in ecosystem assessment

open access: yesEcological Indicators, 2010
Abstract Quantifying relative habitat quality is an important means of ecosystem assessment, and an essential step in the development and validation of indices of biotic integrity (IBI). Variables included in multi-metric IBIs are selected on the basis of their correlation with a human disturbance gradient, and the IBI is tested by examining ...
Rebecca C. Rooney, Suzanne E. Bayley
openaire   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mining-Induced Redistribution of the Abnormal Stress under the Close Bearing Coal Pillar for Entry Design

open access: yesAdvances in Civil Engineering, 2021
Underground space is vulnerable to large deformation influenced by the abnormal stress induced by the bearing coal pillar. A numerical simulation model was established to determine the redistribution of the abnormal stress induced by the mining ...
Xudong Liu   +5 more
doaj   +1 more source

Revisiting fracture gradient: Comments on “A new approaching method to estimate fracture gradient by correcting Matthew–Kelly and Eaton's stress ratio”

open access: yesPetroleum, 2018
A study performed by Marbun et al. [1] claimed that “A new methodology to predict fracture pressure from former calculations, Matthew–Kelly and Eaton are proposed.” Also, Marbun et al.'s paper stated that “A new value of Poisson's and a stress ratio of the formation were generated and the accuracy of fracture gradient was improved.” We found those all ...
Farizal Hakiki, Muizzuddin Shidqi
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Local Elastic Stress Approach for Fatigue Life Calculation by the Finite Element Method (FEM)

open access: yesCommunications, 2004
The paper discusses possibilities of a description of material fatigue and prediction of service life of machine parts on the basis of stress state calculations using the finite element method (FEM).
Milan Ruzicka
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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