Results 61 to 70 of about 227,622 (300)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Study on Reasonable Energy Supplement Time of Tight Sandstone Oil Reservoirs with Rock Compressibility Stress Sensitivity

Geofluids, 2018
A-HBR field is a tight sandstone oil reservoir with a threshold pressure gradient and a rock compressibility stress sensitivity. However, no existing approach could predict reasonable energy supplement time considering both of them.
Tian Xiaofeng, Tan Xianhong, Tian Ji, Li Nan, Yuan Zhongchao, Liang Bin   +5 more
doaj   +1 more source

Micromechanical analysis of kinematic hardening in natural clay

, 2009
This paper presents a micromechanical analysis of the macroscopic behaviour of natural clay. A microstructural stress-strain model for clayey material has been developed which considers clay as a collection of clusters.
Academy of Finland (Grant 210744) (Funder), Helsinki University of technology, , University of Massachusetts, , Academy of Finland (Grant 210744) (Funder), Karstunen, M., , University of Strathclyde, , Ecole Centrale de nates, EC MRTN-CT-2004–512120 (Funder), Yin, Zhen-Yu, , EC MRTN-CT-2004-512120 (Funder), Ecole Centrale de nates, Chang, Ching S., University of Strathclyde, Hicher, Pierre-Yves, , Helsinki University of technology, Karstunen, Minna, University of Massachusetts, Chang, Ching   +17 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Optimization of Welded Joints under Fatigue Loadings

Metals
In this paper, the notch effect in weldments has been investigated, and the optimal configuration of different types of welded joints has been analysed using the implicit gradient approach.
Paolo Livieri, Roberto Tovo
doaj   +1 more source

X-ray analysis of residual stress gradients in TiN coatings by a Laplace space approach and cross-sectional nanodiffraction: a critical comparison [PDF]

Journal of Applied Crystallography, 2013
Novel scanning synchrotron cross-sectional nanobeam and conventional laboratory as well as synchrotron Laplace X-ray diffraction methods are used to characterize residual stresses in exemplary 11.5 µm-thick TiN coatings. Both real and Laplace space approaches reveal a homogeneous tensile stress state and a very pronounced compressive stress gradient in
Stefenelli, Mario, Todt, Juraj, Riedl, Angelika, Ecker, Werner, Müller, Thomas, Daniel, Rostislav, Burghammer, Manfred, Keckes, Jozef   +7 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Flexure Analysis of Functionally Graded Plates Using {2,2}-Refined Zigzag Theory

Havacılık ve Uzay Teknolojileri Dergisi, 2019
This study investigates the flexure analysis of functionally graded (FG) plates using {2,2}-refined zigzag plate theory which considers transverse normal deformation along the thickness of plates.
Mehmet Dorduncu
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nonlocal Gradient Approach on Torsional Vibration of CNTs

, 2018
The nonlocal strain gradient approach for torsional vibration of CNTs have been investigated in the present study. The effects of the stress and strain gradient small scale parameters on the non-dimensional frequencies have been obtained. Strain Gradient
M. Arda (5895359), M. Aydogdu (5895360)
core   +1 more source