Results 31 to 40 of about 66,068 (243)

Stress Hyperglycemia and Outcome of Non-diabetic Patients After Acute Ischemic Stroke

Frontiers in Neurology, 2019
Background and Purpose: Stress hyperglycemia is relative hyperglycemia after suffering an acute illness such as stroke, even without preexisting diabetes.
Bihong Zhu, Bihong Zhu, Bihong Zhu, Yuesong Pan, Yuesong Pan, Jing Jing, Jing Jing, Xia Meng, Xia Meng, Xingquan Zhao, Xingquan Zhao, Liping Liu, Liping Liu, Yilong Wang, Yilong Wang, Yongjun Wang, Yongjun Wang, Zhimin Wang   +17 more
doaj   +1 more source

The association of stress hyperglycemia ratio (SHR) with arterial stiffness: A cross-sectional study. [PDF]

Medicine (Baltimore)
Stress hyperglycemia ratio (SHR) is used to assess the relative increase in blood glucose during stress and is associated with various adverse clinical events. There is evidence suggesting that SHR may be related to an increased risk of cardiovascular mortality.
Chen L, Tian P, Xu Y, Wang Z.
europepmc   +3 more sources

Impacts of stress hyperglycemia ratio on early neurological deterioration and functional outcome after endovascular treatment in patients with acute ischemic stroke

Frontiers in Endocrinology, 2023
Background and PurposeHyperglycemia has been associated with unfavorable outcome of acute ischemic stroke, but this association has not been verified in patients with endovascular thrombectomy treatment.
Zheng Dai, Zheng Dai, Haiming Cao, Feng Wang, Lei Li, Hongquan Guo, Xiaohao Zhang, Haichang Jiang, Juehua Zhu, Yongjun Jiang, Dezhi Liu, Gelin Xu, Gelin Xu, Gelin Xu   +13 more
doaj   +1 more source

Absolute Hyperglycemia versus Stress Hyperglycemia Ratio for the Prognosis of Hospitalized Patients with COVID-19 in the First Months of the Pandemic: A Retrospective Study

Diabetes Therapy, 2022
Diabetes is a risk factor for greater severity of coronavirus disease 2019 (COVID-19). The stress hyperglycemia ratio (SHR) is an independent predictor of critical illness, and it is reported to have a stronger association than absolute hyperglycemia.
Matias, Alexandra A, Manique, Inês, Sabino, Teresa, Rego, Teresa, Mihon, Claudia, Panarra, António, Rizzo, Manfredi, Silva-Nunes, José   +7 more
openaire   +5 more sources

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Mini review: Hyperglycemia in ischemic stroke

Environmental Disease, 2022
The impact of stroke, currently the second leading cause of death worldwide, continues to worsen, and even those that survive can have persistent neurological deficits. A potentially significant implication may be due to hyperglycemia, found in one-third
Honglian Duan, Wesley Kohls, Roxanne Ilagan, Xiaokun Geng, Yuchuan Ding   +4 more
doaj   +1 more source