Results 161 to 170 of about 77,246 (269)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Barriers to post-prostatectomy stress incontinence care: knowledge gaps, patient concerns, and urologist communication. [PDF]

World J Urol
Menzel V, Groeben C, Hoffmann F, Chun FKH, Weissbach L, Thomas C, Huber J, Baunacke M.   +7 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Prediction of success of slings in female stress incontinence, statistical and AI modeling. [PDF]

Sci Rep
Wadie BS, Abdelrasheed A, Taha M, Abdelrahman A, Mohamed B, Saber A, Badawi A.   +6 more
europepmc   +1 more source

Longitudinal Impact of Urinary Diversion on Health‐Related Quality of Life After Radical Cystectomy: A Multicenter Study in Japan

Cancer Science, EarlyView.
This multicenter prospective study examined the impact of urinary diversion on HRQOL among bladder cancer patients who underwent radical cystectomy. Evaluation using the BCI clarified changes in HRQOL related to urinary, bowel, and sexual domains before surgery and at 3, 6, and 12 months postoperatively.
Shuhei Yamada, Miho Sato, Takahiro Osawa, Toru Harabayashi, Jun Miki, Takashi Kobayashi, Katsuyoshi Hashine, Atsunari Kawashima, Takashi Matsumoto, Takanori Mochizuki, Rikiya Taoka, Fumihiko Urabe, Shuichi Tatarano, Atsuro Sawada, Takahiro Kojima, Atsushi Takahashi, Akira Yokomizo, Shigetaka Suekane, Kohei Hashimoto, Yasuhiro Hashimoto, Junji Yatsuda, Ken Morita, Keita Kobayashi, Yohei Satake, Ataru Sazawa, Yoshiyuki Matsui, Yoichi M. Ito, Sayaka Shimizu, Shunichi Fukuhara, Hiroyuki Nishiyama, Hiroshi Kitamura, Nobuo Shinohara, on behalf of the Japanese Urological Oncology Group   +32 more
wiley   +1 more source

Exploring the characteristics of detrusor after contraction in females with pure urodynamic stress incontinence. [PDF]

BMC Urol
Zeng X, Shen H, Luo D, Jin T.
europepmc   +1 more source

Synthetic sling or artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery: the MASTER non-inferiority RCT.

Health Technol Assess, 2022
Constable L, Abrams P, Cooper D, Kilonzo M, Cotterill N, Harding C, Drake MJ, Pardoe MN, McDonald A, Smith R, Norrie J, McCormack K, Ramsay C, Uren A, Mundy T, Glazener C, MacLennan G.   +16 more
europepmc   +1 more source

Stress Incontinence during Different High-Impact Exercises in Women: A Pilot Survey. [PDF]

Int J Environ Res Public Health, 2020
Khowailed IA, Pinjuv-Turney J, Lu C, Lee H.   +3 more
europepmc   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Colposuspension in girls with refractory stress-incontinence, a critical evaluation of a last-resort treatment. [PDF]

Front Urol
van Geen FJ, Nieuwhof-Leppink A, Klijn A, de Kort L, Chrzan R.   +4 more
europepmc   +1 more source