The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Mode I Stress Intensity Factor Solutions for Cracks Emanating from a Semi-Ellipsoidal Pit. [PDF]
Materials (Basel)Saeed H +3 more
europepmc +1 more source
Stress Intensity Factor of Semielliptical Surface Crack in Internally Pressurized Hollow Cylinder-A Comparison between BS 7910 and API 579/ASME FFS-1 Solutions. [PDF]
Materials (Basel), 2019 Coêlho GC +4 more
europepmc +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Unusual Fatigue Crack Growth Behavior of Long Cracks at Low Stress Intensity Factor Ranges. [PDF]
Materials (Basel)Kujawski D, Vasudevan AK.
europepmc +1 more source
Improved Formula for the Stress Intensity Factor of Semi-Elliptical Surface Cracks in Welded Joints under Bending Stress. [PDF]
Materials (Basel), 2017 Peng Y, Wu C, Zheng Y, Dong J.
europepmc +1 more source
Maximum Stress Intensity Factor for a Circumferential Crack in a Finite Length Cylinder under Transient Radial Temperature Distribution [PDF]
A method to evaluate the stress intensity factor of a circumferential crack in a finite length cylinder under non-linear radial temperature distribution, considering the effects of various structural parameters such as cylinder length and edge restraint,
渡邊, 勝彦, 飯井, 俊行
core
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Stress Intensity Factor of Circumferential Crack of Cylinders under Radial Temperature Distribution [PDF]
A simple equation to approximately calculate the stress intensity factor of the circumferential crack of cylinders under axisymmetric bending was derived first. By applying it, and equation to evaluate the stress intensity factor for the same crack under
渡邊, 勝彦, 飯井, 俊行
core
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source