Results 161 to 170 of about 736,903 (219)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of Egg White Powder Supplementation on Nutritional Status, Biochemical Profile, and Oxidative Stress Markers in Diabetic Hemodialysis Patients; A Double-Blind Randomized Controlled Trial. [PDF]

Health Sci Rep
Babaei A, Abdollah Niya H, Hamedi-Shahraki S, Safa J, Tarighat-Esfanjani A.   +4 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Systemic Inflammation and Oxidative Stress Markers in Patients With Medication Overuse Headache. [PDF]

Brain Behav
Li C, He P, Li Y, Ma M, Chen N, Liu Q, Zhang Y, Jiang X, Li S, Lang H, Fang J, He L.   +11 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

An intricate relationship: stress markers and associative memory in a laboratory experiment in older adults. [PDF]

Front Aging Neurosci
Knopf L, Domes G, Kamp SM.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Longitudinal and cross-sectional associations of myocardial stress markers with kidney function and chronic kidney disease in the BiomarCaRE project. [PDF]

Sci Rep
Lin JS, Zeller T, Koenig W, Jousilahti P, Kee F, Iacoviello L, Tunstall-Pedoe H, Söderberg S, Cesana G, Palmieri L, Salomaa V, de Man Lapidoth J, De Ponti R, Donfrancesco C, Lorenz T, Kuulasmaa K, Blankenberg S, Peters A, Thorand B.   +18 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Exploring Potential Correlations Between Oxidative Stress Markers and Inflammatory Pivotal Factors in Children with Hematological Malignancies. [PDF]

Curr Health Sci J
Foia CI, Cosovanu EO, Ghemiș L, Tarțău AM, Cioloca D, Ciubotaru AD, Adumitroaie AE.   +6 more
europepmc   +1 more source