Results 21 to 30 of about 736,903 (219)

Development and non-clinical characterization of Procizumab (invobenitug): a humanized antibody neutralizing circulating DPP3

mAbs
Dipeptidyl peptidase 3 (DPP3) is an intracellular protein involved in cellular antioxidant responses. Upon acute stress and tissue damage, DPP3 is released into the circulation (circulating DPP3, cDPP3), where it induces vascular, cardiac, and immune ...
Magali Genest, Dirk Van Lier, Theo Ikenna Uba, Anika Schroeter, Adrien Picod, Hugo Nordin, Noma Assad, Gwendolyn Marguerit, Alexis Nguyen, Andreas Bergmann, Peter Pickkers, Alexandre Mebazaa, Karine Santos, Feriel Azibani   +13 more
doaj   +1 more source

Preclinical safety evaluation of the dipeptidyl peptidase 3 inhibiting antibody Procizumab in rodents and non-human primates

mAbs
The cytosolic protease dipeptidyl peptidase 3 (DPP3) is released into the circulation upon profound cellular stress. In the bloodstream, circulating DPP3 (cDPP3) rapidly degrades several important mediators of vascular tone.
Dirk van Lier, Magali Genest, Adrien Picod, Francesca Manicone, Bruno Garcia, Theo Ikenna Uba, Anika Schroeter, Karine Santos, Antoine Herpain, Alexis Nguyen, Feriel Azibani, Alexandre Mebazaa, Matthijs Kox, Peter Pickkers   +13 more
doaj   +1 more source

Dietary Corn Silk (Stigma maydis) Extract Supplementation Modulate Production Performance, Immune Response and Redox Balance in Corticosterone-Induced Oxidative Stress Broilers

Animals, 2023
Immunosuppression is a serious consequence of oxidative stress exposure that negatively affects the productivity and profitability of birds, as well as their well-being.
Farid S. Nassar, Abdulaziz M. Alsahlawi, Hasan A. E. Abdellatif, Nancy N. Kamel, Ahmed O. Abbas   +4 more
doaj   +1 more source

Stress Markers Pada Calcaneus Penambang Belerang di Gunung Welirang

Biokultur, 2020
Stress markers adalah tanda pada tulang yang menjadi petunjuk bahwa individu tersebut pernah melakukan suatu pekerjaan yang melibatkan kerjasama otot dan sendi untuk beraktivitas dengan intensitas waktu yang lama dan berulang.
Nadia Amalia
doaj   +1 more source

Biochemical Alterations in Triticale Seedlings Pretreated with Selective Herbicide and Subjected to Drought or Waterlogging Stress

Plants, 2023
Waterlogging and drought disrupt crop development and productivity. Triticale is known to be relatively tolerant to different stress factors. In natural conditions, plants are rather subjected to multiple environmental factors.
Zornitsa Katerova, Dessislava Todorova, Elena Shopova, Liliana Brankova, Ljudmila Dimitrova, Margarita Petrakova, Iskren Sergiev   +6 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Reconstructing the Demography of Kalmykia’s Catacomb Population: A Study of Excavated Archaeological Materials, 1981–2008

Oriental Studies, 2023
Introduction. The publication finalizes the series of paleodemographic studies into materials from Catacomb burials discovered by archaeologists in grave mounds across the three territorial zones of Kalmykia — Sarpa Lowland, Yergeni Upland, and Caspian ...
Lidzhikova Tatiana V., Bembeeva Lyubov A.   +1 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Galectin-3/CD146 interaction promotes renal damage and systemic inflammation after acute kidney injury

Scientific Reports
Galectin-3 (Gal-3) expression is abnormally increased after renal ischemic injury, in various studies, further promoting tissue damage. Gal-3 may interact with the endothelial layer to induce inflammation during renal injury, linking the systemic and ...
L. Boutin, S. M. Figueroa, E. Roger, S. Hadjadj, R. Piedagnel, E. Gayat, J.-L. Samuel, M. Legrand, F. Dépret, Christos E. Chadjichristos   +9 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source