Results 51 to 60 of about 9,272,105 (348)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Optimization Method of Production System for Coalbed Methane Wells throughout Life Cycle

Energies
Different from conventional gas reservoirs, the permeability of coalbeds is affected by stress sensitivity and matrix shrinkage during production. These two conditions lead to lower permeability in the reservoir and affect the production efficiency of ...
Chen Li, Lichun Sun, Zhigang Zhao, Jian Zhang, Cunwu Wang, Gang Lei, Yong Li, Yanjun Meng   +7 more
doaj   +1 more source

Research on Transformation of Connate Water to Movable Water in Water-Bearing Tight Gas Reservoirs

Energies, 2023
The Dongsheng gas field is a water-bearing tight gas reservoir characterized by high connate water saturation. During gas production, the transformation of connate water into movable water introduces a unique water production mode, significantly ...
Fuhu Chen, Zengding Wang, Shuaishi Fu, Aifen Li, Junjie Zhong   +4 more
doaj   +1 more source

An Experimental Study on Stress Sensitivity of Tight Sandstones with Different Microfractures

Advance in Civil Engineering, 2020
Aiming at the stress sensitivity problem of tight reservoirs with different microfractures, the cores of H oilfield and J oilfield with different microfractures were obtained through the fractures experiment, so as to study the change of gas permeability
Xinli Zhao, Zhengming Yang, Zhiyuan Wang, Wei Lin, S. Xiong, Yutian Luo, Zhongkun Niu, Debin Xia   +7 more
semanticscholar   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

An advanced fractal-based well testing model capturing fracture complexity in low permeability tight gas reservoirs

Frontiers in Energy Research
The study of heterogeneous and complex oil and gas reservoirs poses a significant challenge due to the problem of unstable seepage flow. This research investigates the non-linear seepage flow patterns in such reservoirs, with a particular focus on ultra ...
Kun Wang, Kun Wang, Li Li, Mingying Xie, Jianwen Dai, Shasha Feng, Min Li, Ruijie Huang, Siyu Liu   +8 more
doaj   +1 more source

Strain sensing based on radiative emission-absorption mechanism using dye-doped polymer optical fiber [PDF]

, 2017
A stress sensor based on a dye-doped polymeric optical fiber is able to detect stress by simple comparison of two luminescence peaks from a pair of energy transfer organic dyes. Coumarin 540A (donor) and Rhodamine 6G (acceptor) were doped in the core and
R. Furukawa, S. Kamimura
core   +2 more sources

Adaptation and Sensitization to Proteotoxic Stress

Dose-Response, 2013
Although severe stress can elicit toxicity, mild stress often elicits adaptations. Here we review the literature on stress-induced adaptations versus stress sensitization in models of neurodegenerative diseases. We also describe our recent findings that chronic proteotoxic stress can elicit adaptations if the dose is low but that high-dose proteotoxic
openaire   +3 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Coupled Productivity Prediction Model for Multi-Stage Fractured Horizontal Wells in Low-Permeability Reservoirs Considering Threshold Pressure Gradient and Stress Sensitivity

Energies
Multi-stage fractured horizontal wells (MSFHWs) represent a crucial development approach for low-permeability reservoirs, where accurate productivity prediction is essential for production operations. However, existing models suffer from limitations such
Long Xiao, Ping Yue, Hongnan Yang, Wei Guo, Simin Qu, Hui Yao, Lingqiang Meng   +6 more
doaj   +1 more source