Results 171 to 180 of about 807,773 (347)

SEX DIFFERENCES IN THE NEURAL CIRCUITS THAT PREDICT ALCOHOL DEPENDENCE

Although neurobiological mechanisms underlying alcohol use and dependence have been extensively researched, mechanisms explaining sex differences in alcohol drinking are poorly understood. The cortical-striatal circuit plays a key role in the development
Hewitt, Kelly
core   +1 more source

Neurobiology of negative reinforcement as a driving force in alcohol addiction. [PDF]

Neuron
Vendruscolo LF, Koob GF.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Persistency of financial distress amongst Italian households: evidence from dynamic probit models

This paper analyses financial distress among Italian households using the longitudinal component of the Bank of Italy Survey on Household Income and Wealth (SHIW) for the period 1998-2006. It aims to test whether the probability of experiencing financial
Elena Giarda
core  

Academic involution atmosphere and AI dependence among university students: the mediating role of academic stress and the moderating role of individual academic involution behaviors. [PDF]

Front Psychol
Fu F.
europepmc   +1 more source

Erratum to: “Plane stress state problems for notched bodies whose plastic properties depend on the form of the stress state” [PDF]

Mechanics of Solids, 2013
E. V. Lomakin, A. M. Mel’nikov
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Quantitative Wear Models for Microscale Material Removal. [PDF]

Nanomaterials (Basel)
Luo K, Chen S, Li H, Liang J, Sheng M, Tan Q, Wang Y, She D, Zhong L.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source