Results 81 to 90 of about 8,215,212 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Investigating the relationship between stressful life events, coping style and Parkinson's disease [PDF]

, 2011
Section A gives an overview of Parkinson’s disease (PD), followed by a review of physiological and psychological literature suggestive of a relationship between stress and illness, with special consideration given to neurological disorders, including PD.
Underwood, H.
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Mediation model being tested; cognitive emotion regulation strategies as mediator of depressive symptoms after a stressful life event.

, 2016
Mediation model being tested; cognitive emotion regulation strategies as mediator of depressive symptoms after a stressful life event.
Denise H. M. Bodden (3090726), Anneloes L. van Baar (782706), Yvonne Stikkelbroek (704976), Mirjam Reijnders (3090723), Marloes Kleinjan (451400)   +4 more
core   +1 more source

Feasibility and preliminary effects of an individually customizable ecological momentary stress management intervention: A mixed methods pilot study

Internet Interventions
While many interventions are known to reduce stress, evidence-based stress management interventions that can be applied during stressful events in everyday life are lacking.
Hannah Tschenett, Aljoscha Dreisörner, Katrin Schäfer, Ricarda Mewes, Urs M. Nater   +4 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Impact of new traumatic or stressful life events on pre-existing PTSD in traumatized refugees: results of a longitudinal study

, 2023
Background: A significant proportion of trauma survivors experience an additional critical life event in the aftermath. These renewed experiences of traumatic and stressful life events may lead to an increase in trauma-related mental health symptoms ...
Maria Böttche (8350212), Katrin Schock (14338665), Rita Rosner (5126798), Christine Knaevelsrud (631911), Mechthild Wenk-Ansohn (14338668)   +4 more
core   +1 more source

Investigating the association between stressful life events and the risk of myocardial infarction and mortality: the Tromsø study

BMC Cardiovascular Disorders
Background Psychosocial stress is increasingly recognized as an independent risk factor for cardiovascular disease. However, the long-term impact of cumulative stressful life events on the risk of myocardial infarction (MI) and mortality in the general ...
Geir Fagerjord Lorem, Kjersti Lillevoll, Maja-Lisa Løchen, Tom Wilsgaard, Jens C. Thimm, Catharina Elisabeth Arfwedson Wang, Henrik Schirmer   +6 more
doaj   +1 more source