Results 101 to 110 of about 5,454,379 (294)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Proposed Physiological and Neurobiological Mechanisms of Music’s Effect, with a Focus on the Perioperative Period: Literature Evidence from Human, Canine and Feline Medicine

Veterinary Sciences
There is growing evidence regarding non-pharmacological therapies such as music as a supportive approach for the treatment of various clinical conditions in humans.
Stefanos G. Georgiou, Apostolos D. Galatos   +1 more
doaj   +1 more source

Stressful Life Events, Sleep, Mood, and Depression in Mothers and Fathers During Pregnancy and the Postpartum Period

Objective: The birth of a baby is a time of great change. Changes in parents’ mood and sleep are considerably higher during pregnancy and after the birth of the child, which can put a strain on the health of parents and infants.
Svetlana B. Leshchinskaia, Yulia Kovas, Olga V. Terekhina, Habib Niyaraq Nobakht, Tatiana G. Bokhan, Alice M. Gregory   +5 more
core   +1 more source

Stressful life events and the onset of asthma

, 2010
The status of stressful life events as a risk factor for asthma is unclear and may be dependent on pre-existing allergic rhinitis. This study examined whether exposure to stressful life events predicted the onset of asthma in adults.
L. Sillanmaki, Vahtera, J., M. Kivimaki, Sillanmaki, L., M. Koskenvuo, R. Lietzen, Lietzen, R., Virtanen, Pekka,, P. Virtanen, J. Vahtera, Kivimaki, M., Koskenvuoe, M.   +11 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Unraveling the relationship between stress exposure and childhood anxiety: Considering accumulation, impact, and type in the first five years of life.

PLoS ONE
Exposure to stressful events is linked to anxiety symptoms in children, although research examining this association in the first five years of life is limited.
Viviane Valdes, Linda W Craighead, Charles A Nelson, Michelle Bosquet Enlow   +3 more
doaj   +1 more source

Validation of the Arabic version of the Cohen perceived stress scale (PSS-10) among pregnant and postpartum women

BMC Psychiatry, 2010
Background This study was conducted to evaluate the validity of the Arabic translation of the Cohen Perceived Stress Scale (PSS-10) in pregnant and postpartum women. Methods A sample of 268 women participated.
Naassan Georges, Osman Hibah, Chaaya Monique, Mahfoud Ziyad   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

Influence of anxiety and reported stressful life events on relapses in multiple sclerosis: a prospective study

, 2008
Objective Self-reported stressful life events and infections have been associated with relapses in multiple sclerosis. Also, anxiety has been reported to influence other diseases of unpredictable course.
Mitropoulos, P. A., Mitsonis, C., Vassilopoulos, D., Sfagos, C., Potagas, C., Watier, L., Retziou, A., Dellatolas, G.   +7 more
core   +1 more source